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QUANTITATION OF ALFUZOSIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC

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dc.contributor.author GANESH, MANI
dc.contributor.author UPPATYAY, SATISH
dc.contributor.author TIVARI, RISHI
dc.contributor.author KAMALAKANNAN, KALIAPPAN
dc.contributor.author RATHINAVEL, GOVINDASAMY
dc.contributor.author GANGULLY, SWASTIKA
dc.contributor.author SIVAKUMAR, THANGAVEL
dc.date.accessioned 2022-11-29T03:34:03Z
dc.date.available 2022-11-29T03:34:03Z
dc.date.issued 2009-07-04
dc.identifier.citation Ganesh, M., Uppatyay, S., Tivari, R., Kamalakannan, K., Rathinavel, G., Gangully, S., & Sivakumar, T. (2009). Quantitation of alfuzosin hydrochloride in pharmaceutical formulations by RP-HPLC. Pak. J. Pharm. Sci, 22(3), 263-266. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14142
dc.description.abstract An isocratic reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 245 nm has been developed for the determination of alfuzosin hydrochloride in dosage formulation. Good chromatographic separation alfuzosin was achieved by using a stainless steel analytical column Inertsil ODS-3V (5µm, 15 cm x 0.46 cm). The system was operated at ambient temperature (25 ±2˚C) using a mobile phase consisting of acetonitrile : water : tetrahydrofuran : perchloricacid (250:740:10:1) at a flow rate of 1 ml/min. The calibration curve for alfuzosin hydrochloride was linear over the tested concentration range of 50%, 75%, 100%, 125% and 150% with reference to the label claim and a correlation coefficient of 0.999. The intra- and inter-run precision and accuracy results were 98.07 to 100.34 with the %RSD of 0.71% and tailings factor 1.07. The proposed method was validated for its selectivity, linearity, accuracy, and precision. The method was found to be suitable for the quality control of alfuzosin hydrochloride in bulk drug as well as in formulation. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Alfuzosin en_US
dc.subject UV detection en_US
dc.subject RP-HPLC en_US
dc.subject dosage formulation en_US
dc.subject method validation en_US
dc.title QUANTITATION OF ALFUZOSIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC en_US
dc.type Article en_US


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