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COMPARISON OF HYPOTENSIVE AND HYPOLIPIDEMIC EFFECTS OF CATHARANTHUS ROSEUS LEAVES EXTRACT WITH ATENOLOL ON ADRENALINE INDUCED HYPERTENSIVE RATS

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dc.contributor.author ARA, NAZNIN
dc.contributor.author RASHID, MAMUNUR
dc.contributor.author AMRAN, MD SHAH
dc.date.accessioned 2022-11-29T03:37:07Z
dc.date.available 2022-11-29T03:37:07Z
dc.date.issued 2009-07-05
dc.identifier.citation Ara, N., Rashid, M., & Amran, S. (2009). Comparison of hypotensive and hypolipidemic effects of Catharanthus roseus leaves extract with atenolol on adrenaline induced hypertensive rats. Pakistan Journal of Pharmaceutical Sciences, 22(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14143
dc.description.abstract The leaves extract of Catharanthus roseus was investigated for hypotensive and hypolipidemic effects in adrenaline-induced hypertensive rats (AIHR) and compared with those of Atenolol in a crossover design. The pharmacologically Active components responsible for hypotensive activities were isolated from plant using bioassay guided purification approach and the structure of the compounds was proposed by spectroscopic methods. Catharanthus roseus leaves extract and commercial drug Atenolol were administered through intraperitoneal (i.p) route for one week. Different biochemical parameters such as heart weight, blood glucose level, serum cholesterol level, serum triglyceride level, body weight and the relationships between them were measured. Catharanthus roseus leaves extract at a dose of 30 mg/155±15 gm of body weight was injected in rat at every morning during the treatment period. The dose of Atenolol was determined according to its pharmacokinetic parameters. Clinically effective plasma concentration as a hypotensive drug was obtained after the injection of 0.1 mg/155±15 gm of body weight of the drug. The Catharanthus roseus leaves extract made significant changes in each cardiovascular parameter after investigation. Catharanthus roseus leaves extract treated animals have shown the hypotensive effects. Hypotensive effects were also shown by Atenolol. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Hypertension en_US
dc.subject antihypertensive en_US
dc.subject catharanthus roseus en_US
dc.subject atenolol en_US
dc.subject adrenaline en_US
dc.title COMPARISON OF HYPOTENSIVE AND HYPOLIPIDEMIC EFFECTS OF CATHARANTHUS ROSEUS LEAVES EXTRACT WITH ATENOLOL ON ADRENALINE INDUCED HYPERTENSIVE RATS en_US
dc.type Article en_US


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