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EFFECT OF AQUEOUS EXTRACTS OF ALLIGATOR PEAR SEED (PERSEA AMERICANA MILL) ON BLOOD GLUCOSE AND HISTOPATHOLOGY OF PANCREAS IN ALLOXAN-INDUCED DIABETIC RATS

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dc.contributor.author EDEM, DO
dc.contributor.author EKANEM, IS
dc.contributor.author EBONG, PE
dc.date.accessioned 2022-11-29T03:47:43Z
dc.date.available 2022-11-29T03:47:43Z
dc.date.issued 2009-07-06
dc.identifier.citation Edem, D. O., Ekanem, I. S., & Ebong, P. E. (2009). Effect of aqueous extracts of alligator pear seed (Persea americana mill) on blood glucose and histopathology of pancreas in alloxan-induced diabetic rats. Pak J Pharm Sci, 22(3), 272-276. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14144
dc.description.abstract Effects of aqueous extract of alligator pear seed on normal and alloxan-induced diabetic rats were investigated in 6 groups of rats (5 rats per group). Test groups were made diabetic with intra-peritoneal injection of alloxan and treated with 300mg and 600mg/kg body weight of alligator pear seed extract. Two non-diabetic groups were also administered with 300mg and 600mg/kg body weight extract. The levels of blood glucose were examined in all 6 experimental groups. In diabetic rats, blood glucose levels were significantly reduced (p < 0.05) by 73.26-78.24% on consumption of the extracts, with greater effect exhibited by the 600mg/kg extract. In normal rats, blood glucose levels were significantly reduced (p < 0.05) by 34.68-38.9% on consumption of the seed extract. Histological studies showed a degenerative effect on the pancreatic islet cells of diabetic rats. The result suggested restorative (protective) effect of the extract on pancreatic islet cells. Administration of aqueous extract of alligator pear seed may contribute significantly to the reduction of blood glucose levels and can be useful in the treatment of diabetes. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Alligator pear en_US
dc.subject Persia americana en_US
dc.subject seed extract en_US
dc.subject hypoglycemic effects en_US
dc.title EFFECT OF AQUEOUS EXTRACTS OF ALLIGATOR PEAR SEED (PERSEA AMERICANA MILL) ON BLOOD GLUCOSE AND HISTOPATHOLOGY OF PANCREAS IN ALLOXAN-INDUCED DIABETIC RATS en_US
dc.type Article en_US


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