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ANTINOCICEPTIVE AND ANTI-PYRETIC ACTIVITY OF BENINCASA HISPIDA (THUNB.) COGN. IN WISTAR ALBINO RATS

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dc.contributor.author LATIEF QADRIE, ZULFKAR
dc.contributor.author TAYEB HAWISA, NAJAT
dc.contributor.author WAJID ALI KHAN, MOHD.
dc.contributor.author SAMUEL, MOSES
dc.contributor.author ANANDAN, R
dc.date.accessioned 2022-11-29T04:00:20Z
dc.date.available 2022-11-29T04:00:20Z
dc.date.issued 2009-07-10
dc.identifier.citation Qadrie, Z. L., Hawisa, N. T., Khan, M., Ali, W., Samuel, M., & Anandan, R. (2009). Antinociceptive and anti-pyretic activity of Benincasa hispida (thunb.) cogn. in Wistar albino rats. Pakistan Journal of Pharmaceutical Sciences, 22(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14147
dc.description.abstract The seeds of Benincasa hispida (Thunb) COGN. (Family: Cucurbitaceae) was extracted with ethanol and was used to study acute toxicity, antinociceptive and anti-pyretic effects. Brewer’s yeast (15%) was used to induce pyrexia in rats. The extract was non lethal to the rats up to the dose of 5000 mg/kg b.w. At doses of 250 and 500 mg/kg b.w, the extract significantly (P<0.05) increased the antinociceptive effective in a dose dependent manner in rats. Similarly, at doses of 250 and 500 mg/kg b.w the extract significantly (P<0.05) decreased yeastinduced pyrexia in rats. These results indicate that ethanolic extract of Benincasa hispida possesses potent antinociceptive and antipyretic effects and thus pharmacologically justifying its folkloric use in the management of fever and pain conditions. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Benincasa hispida en_US
dc.subject Brewer’s yeast en_US
dc.subject antinociceptive en_US
dc.subject anti-pyretic effects en_US
dc.subject acute toxicity en_US
dc.title ANTINOCICEPTIVE AND ANTI-PYRETIC ACTIVITY OF BENINCASA HISPIDA (THUNB.) COGN. IN WISTAR ALBINO RATS en_US
dc.type Article en_US


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