dc.contributor.author |
LATIEF QADRIE, ZULFKAR |
|
dc.contributor.author |
TAYEB HAWISA, NAJAT |
|
dc.contributor.author |
WAJID ALI KHAN, MOHD. |
|
dc.contributor.author |
SAMUEL, MOSES |
|
dc.contributor.author |
ANANDAN, R |
|
dc.date.accessioned |
2022-11-29T04:00:20Z |
|
dc.date.available |
2022-11-29T04:00:20Z |
|
dc.date.issued |
2009-07-10 |
|
dc.identifier.citation |
Qadrie, Z. L., Hawisa, N. T., Khan, M., Ali, W., Samuel, M., & Anandan, R. (2009). Antinociceptive and anti-pyretic activity of Benincasa hispida (thunb.) cogn. in Wistar albino rats. Pakistan Journal of Pharmaceutical Sciences, 22(3). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14147 |
|
dc.description.abstract |
The seeds of Benincasa hispida (Thunb) COGN. (Family: Cucurbitaceae) was extracted with ethanol and was
used to study acute toxicity, antinociceptive and anti-pyretic effects. Brewer’s yeast (15%) was used to induce
pyrexia in rats. The extract was non lethal to the rats up to the dose of 5000 mg/kg b.w. At doses of 250 and 500 mg/kg b.w, the extract significantly (P<0.05) increased the antinociceptive effective in a dose dependent
manner in rats. Similarly, at doses of 250 and 500 mg/kg b.w the extract significantly (P<0.05) decreased yeastinduced pyrexia in rats. These results indicate that ethanolic extract of Benincasa hispida possesses potent antinociceptive and antipyretic effects and thus pharmacologically justifying its folkloric use in the management of fever and pain conditions. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
en_US |
dc.subject |
Benincasa hispida |
en_US |
dc.subject |
Brewer’s yeast |
en_US |
dc.subject |
antinociceptive |
en_US |
dc.subject |
anti-pyretic effects |
en_US |
dc.subject |
acute toxicity |
en_US |
dc.title |
ANTINOCICEPTIVE AND ANTI-PYRETIC ACTIVITY OF BENINCASA HISPIDA (THUNB.) COGN. IN WISTAR ALBINO RATS |
en_US |
dc.type |
Article |
en_US |