PASTIC Dspace Repository

A COMPARATIVE STUDY OF VARIOUS MICROENCAPSULATION TECHNIQUES: EFFECT OF POLYMER VISCOSITY ON MICROCAPSULE CHARACTERISTICS

Show simple item record

dc.contributor.author MURTAZA, GHULAM
dc.contributor.author AHAMD, MAHMOOD
dc.contributor.author AKHTAR, NAVEED
dc.contributor.author RASOOL, FATIMA
dc.date.accessioned 2022-11-29T04:04:26Z
dc.date.available 2022-11-29T04:04:26Z
dc.date.issued 2009-07-10
dc.identifier.citation Murtaza, G., Ahamd, M., Akhtar, N., & Rasool, F. (2009). A comparative study of various microencapsulation techniques: Effect of polymer viscosity on microcapsule characteristics. Pak. J. Pharm. Sci, 22(3), 291-300. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14148
dc.description.abstract It is a comparative study of salbutamol sulpahte-ethylcellulose microcapsules prepared by three different microencapsulation techniques i.e. coacervation thermal change, solvent evaporation and coacervation nonsolvent addition by adjusting the ratio of salbutamol sulpahte to ethylcellulose. In vitro release profiles of microcapsules were studied using USP XXIV dissolution apparatus-I in 450 ml double distilled water maintained at 37°C at 50 rpm. Scanning electron microscopic results indicated that all microcapsules were aggregated, whitish and irregular in shape with good entrapment efficiency (86.34 to 97.83), production yield (87.91±1.34 to 98.33±1.37) and flow properties. Initial burst effect was observed in the drug release behavior from all microcapsules. A slight increase in actual drug loading but profound increase in mean diameter of microcapsules was observed with the increase in the viscosity of ethylcellulose. UV and FTIR spectroscopy, x-ray diffractometry and thermal analysis verified the absence of any strong chemical interaction between drugs and polymer. The drug release from all the formulations followed anomalous diffusion mechanism and was best fit to Higuchi’s kinetic model. The results suggest coacervation thermal change as an appropriate approach to develop slow-release multi-unit oral dosage form of salbutamol sulpahte suggesting at least twice administration in every 24 hours. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Salbutamol sulphate en_US
dc.subject microencapsulation en_US
dc.subject ethylcellulose en_US
dc.subject coacervation en_US
dc.subject solvent evaporation en_US
dc.subject viscosity grade en_US
dc.title A COMPARATIVE STUDY OF VARIOUS MICROENCAPSULATION TECHNIQUES: EFFECT OF POLYMER VISCOSITY ON MICROCAPSULE CHARACTERISTICS en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account