Abstract:
The purpose of the present study was to investigate the effect of channeling agent on the release profile of
theophylline from Kollidon SR based matrix systems. Matrix tablets of theophylline using Kollidon SR which is
plastic in nature were prepared by direct compression process. NaCl and PEG 1500 were used as channeling
agents. Drug release study was evaluated for eight hours using USP 22 paddle-type dissolution apparatus using
distilled water as the dissolution medium. The release mechanisms were explored and explained with zero
order, Higuchi, first order and Korsmeyer equations. The release rate, extent and mechanisms were found to be governed by the type and content of the channeling agents. Increased rate and extent of the drug release were found by using higher content of channeling agent (42.49%) in the matrix due to increased porosity when
compared with the formulation having no channeling agents. On the other hand decreased rate and extent of
drug release were observed in the formulation having lower channeling agent content (19.76%). PEG 1500
ensures maximum release of drug from Kollidon SR than NaCl when other parameters were kept unchanged. It was found that type and amount of channeling agent significantly affect the time required for 50% of drug
release (T50%), percentage drug release at 8 hours, release rate constant (K) and diffusion exponent (n). Kinetic modeling of dissolution profiles revealed drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport, which was mainly dependent on the type and amount of channeling agents. These studies indicate that the proper balance between a matrix forming agent and a channeling agent can produce a drug dissolution profile similar to a desired dissolution profile.
