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EFFECT OF CHANNELING AGENTS ON THE RELEASE PATTERN OF THEOPHYLLINE FROM KOLLIDON SR BASED MATRIX TABLETS

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dc.contributor.author MILLAT IBN RAZZAK, MD. SHAIKHUL
dc.contributor.author KHAN, FERDOUS
dc.contributor.author HOSSAIN, MASUMA
dc.contributor.author RAHMAN KHAN, MD. ZIAUR
dc.contributor.author ABUL KALAM AZAD, MOHAMMAD
dc.contributor.author REZA, MD. SELIM
dc.date.accessioned 2022-11-29T04:16:35Z
dc.date.available 2022-11-29T04:16:35Z
dc.date.issued 2009-07-12
dc.identifier.citation Razzak, S. M. I., Khan, F., Hossain, M., Khan, Z. R., Azad, M. A. K., & Reza, S. (2009). Effect of channeling agents on the release pattern of theophylline from kollidon SR based matrix tablets. Pakistan Journal of Pharmaceutical Sciences, 22(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14150
dc.description.abstract The purpose of the present study was to investigate the effect of channeling agent on the release profile of theophylline from Kollidon SR based matrix systems. Matrix tablets of theophylline using Kollidon SR which is plastic in nature were prepared by direct compression process. NaCl and PEG 1500 were used as channeling agents. Drug release study was evaluated for eight hours using USP 22 paddle-type dissolution apparatus using distilled water as the dissolution medium. The release mechanisms were explored and explained with zero order, Higuchi, first order and Korsmeyer equations. The release rate, extent and mechanisms were found to be governed by the type and content of the channeling agents. Increased rate and extent of the drug release were found by using higher content of channeling agent (42.49%) in the matrix due to increased porosity when compared with the formulation having no channeling agents. On the other hand decreased rate and extent of drug release were observed in the formulation having lower channeling agent content (19.76%). PEG 1500 ensures maximum release of drug from Kollidon SR than NaCl when other parameters were kept unchanged. It was found that type and amount of channeling agent significantly affect the time required for 50% of drug release (T50%), percentage drug release at 8 hours, release rate constant (K) and diffusion exponent (n). Kinetic modeling of dissolution profiles revealed drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport, which was mainly dependent on the type and amount of channeling agents. These studies indicate that the proper balance between a matrix forming agent and a channeling agent can produce a drug dissolution profile similar to a desired dissolution profile. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Channeling agent en_US
dc.subject theophylline en_US
dc.subject release profile en_US
dc.subject Kollidon SR en_US
dc.title EFFECT OF CHANNELING AGENTS ON THE RELEASE PATTERN OF THEOPHYLLINE FROM KOLLIDON SR BASED MATRIX TABLETS en_US
dc.type Article en_US


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