PASTIC Dspace Repository

EFFECT OF METHANOLIC EXTRACT OF HYOSCYMUS NIGER L. ON THE SEIZURE INDUCED BY PICRITOXIN IN MICE

Show simple item record

dc.contributor.author MAHMOUD REZA, HEIDARI
dc.contributor.author MOHAMMAD, HEIDARI
dc.contributor.author GOLNAZ, EIMANI
dc.contributor.author GHOLAMREZA, SEPEHRI
dc.date.accessioned 2022-11-29T04:20:16Z
dc.date.available 2022-11-29T04:20:16Z
dc.date.issued 2009-07-13
dc.identifier.citation Reza, H. M., Mohammad, H., Golnaz, E., & Gholamreza, S. (2009). Effect of methanolic extract of Hyoscymus niger L. on the seizure induced by picritoxin in mice. Pakistan Journal of Pharmaceutical Sciences, 22(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14151
dc.description.abstract Effects of Hyoscyamus niger L on central nervous system have been known for many years. The effects of methanolic extract of H. niger L. on seizures induced by picrotoxin was studied in mice in this investigation. In this study 7 groups of animals pretreated with methanolic extract of the plant (12.5, 25, 50, 100, 200, 300, 400 mg/kg/i.p.), 20 minutes prior to the picrotoxin (12 mg/kg/ i.p.) – induced seizures. Control mice received phenobarbital (40mg/kg/ i.p.) as positive control, or saline (10 ml/kg) as negative control. The latency of seizure (sec), duration of seizure (sec) and mortality rate were determined in test and control groups. The results of this study showed that latency of seizure was increased in groups that were pretreated with doses of 100, 200, 300 and 400 mg/kg of extract. In addition, methanolic extract of H. niger L. delayed the death time in mice as compared to control that was significant with doses of 200, 300 and 400 mg/kg. The most effective dose of extract was 300 mg/kg in this investigation (P < 0.01). In conclusion, the results showed that methanolic extract of H. niger L. posses the anticonvulsant activity against picrotoxin-induced seizures in mice. The exact mechanism(s) by which the plant exerts its anticonvulsant activity is not determined yet. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Hyoscyamus niger L en_US
dc.subject seizure en_US
dc.subject picrotoxin en_US
dc.subject mice en_US
dc.title EFFECT OF METHANOLIC EXTRACT OF HYOSCYMUS NIGER L. ON THE SEIZURE INDUCED BY PICRITOXIN IN MICE en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account