Abstract:
Effects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain
damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into
four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical
procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in
the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in
the control group. CAPE was administered after MCA occlusion at the dose of 10µg/kg, once a day
intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7.
Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE
significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating
increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective
agent.
