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SIMULTANEOUS DETERMINATION OF METRONIDAZOLE AND MICONAZOLE NITRATE IN GEL BY HPTLC

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dc.contributor.author B. MESHRAM, DHANANJAY
dc.contributor.author B. BAGADE, SHASHIKANT
dc.contributor.author R. TAJNE, MADHUKAR
dc.date.accessioned 2022-11-29T04:37:45Z
dc.date.available 2022-11-29T04:37:45Z
dc.date.issued 2009-07-16
dc.identifier.citation Meshram, D. B., Bagade, S. B., & Tajne, M. R. (2009). Simultaneous determination of metronidazole and miconazole nitrate in gel by HPTLC. Pakistan Journal of Pharmaceutical Sciences, 22(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14154
dc.description.abstract A new, simple, precise, rapid and selective high-performance thin-layer chromatographic (HPTLC) method for the simultaneous quantification of Metronidazole (MTZ) and Miconazole nitrate (MCZ) in gel has been developed. It was performed on silica gel 60 GF254 Thin Layer Chromatographic plates using mobile phase comprising of Toluene: Chloroform: Methanol (3.0:2.0:0.6 v/v) and the detection was carried out at 240 nm using densitometer. The retention factors of MTZ and MCZ were 0.34 and 0.55 respectively. Calibration curves were linear in the range of 300-700 ng/spot of MTZ and 600-1400 ng/spot of MCZ both by height and by area. The percent recovery of the drugs from gel carried out by standard addition method was found to be 100.13±1.59 (by height) and 98.92±0.76 (by area) for MTZ and 99.49±1.58 (by height) and 99.63±1.46 (by area) for MCZ indicative of accuracy and precision of simultaneous determination of MTZ and MCZ nitrate. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Metronidazole en_US
dc.subject miconazole nitrate en_US
dc.subject HPTLC en_US
dc.subject Gel en_US
dc.title SIMULTANEOUS DETERMINATION OF METRONIDAZOLE AND MICONAZOLE NITRATE IN GEL BY HPTLC en_US
dc.type Article en_US


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