Abstract:
Bioavailabilities of seven tablets of ciprofloxacin were determined. The co-rrelation between in-vivo
bioavailability parameters and in-vitro dissolution rates were studied. Ciprofloxacin concentration from the
blood was determined by microbiological assay technique. The release pattern of ciprofloxacin from tablets,
which were determined by dissolution USP paddle method and spectrophotometric method was used to
determine the concentration. All the parameters of ciprofloxacin bioavailability i.e., Tmax, Cmax, AUC and
absorption rate constant (Ka) showed no significant correlation with dissolution rates at T30%, T50%, T90%
and dissolution at 30 mins with aims as in-vivo bioequvalence waiver. The value of dissolution test used as
quality tool for predicting in-vivo performance of drug product is significantly enhanced, if the in-vivo – invitro relationship (correlation or association) is established.
