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ANTIBIOTIC PRODUCTION BY THERMOPHILIC BACILLUS SPECIE SAT-4

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dc.contributor.author MUHAMMAD, SYED AUN
dc.contributor.author AHMAD, SAFIA
dc.contributor.author HAMEED, ABDUL
dc.date.accessioned 2022-11-29T05:01:06Z
dc.date.available 2022-11-29T05:01:06Z
dc.date.issued 2009-07-19
dc.identifier.citation Muhammad, S. A., Ahmad, S., & Hameed, A. (2009). ANTIBIOTIC PRODUCTION BY THERMOPHILIC BACILLUS SPECIE SAT-4. Pakistan journal of pharmaceutical sciences, 22(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14158
dc.description.abstract Production of antimicrobial compounds seems to be a general phenomenon for most bacteria. The prevalence of antimicrobial resistance among key microbial pathogens is increasing at an alarming rate worldwide. Current solutions involve development of a more rationale approach to antibiotic use and discover of new antimicrobials. Bacillus species produce a large number of biological compounds active against bacteria, fungi, protozoa and viruses. The process of production usually involves screening of wide range of microorganisms, testing and modification. Production is carried out using fermentation. Thermophilic spore-forming, gram positive, motile rod bacterial strains were isolated from the Thar Desserts, Sindh Province, Pakistan. These strains were screened and checked for antibacterial activity. The best activity was observed by SAT4 against Micrococcus luteus, Staphylococcus aureus and Pseudomonas aeroginosa. The activity was only observed against gram positive bacteria and no activity was seen against Pseudomonas aeroginosa. Thermophilic Bacillus specie SAT4 was found to be active in the fermentation process to produce the antimicrobial agents. Further optimizations of different conditions (time of incubation, media, pH, glucose concentrations, nitrogen concentrations, and temperature) for antimicrobial production by the selected bacterial strain was performed. Agar diffusion assay was performed to evaluate the antibacterial activity. Optimum conditions for the production of antimicrobials by selected isolate were observed to be 48 hour, pH 5, temperature 55°C, 2% glucose and 1.5% nitrogen concentration. This newly isolated bacterial strain has great potential for antimicrobial production at industrial scale. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Thermophiles en_US
dc.subject Bacillus species en_US
dc.subject antibiotics production en_US
dc.title ANTIBIOTIC PRODUCTION BY THERMOPHILIC BACILLUS SPECIE SAT-4 en_US
dc.type Article en_US


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