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CEPHRADINE ANTACIDS INTERACTION STUDIES

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dc.contributor.author ARAYNE, M. SAEED
dc.contributor.author SULTANA, NAJMA
dc.contributor.author AFZAL, M.
dc.date.accessioned 2022-11-29T05:05:47Z
dc.date.available 2022-11-29T05:05:47Z
dc.date.issued 2007-07-20
dc.identifier.citation Arayne, M. S., Sultana, N., & Afzal, M. (2007). Cephradine antacids interaction studies. Pak. J. Pharm. Sci, 20(3), 175-179. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14162
dc.description.abstract The present work comprises of interaction studies of cephradine with antacids. Cephradine is included among the first generation cephalosporin, which is active against a wide range of Gram positive and Gram-negative bacteria including penicillinase-producing staphylococci. Since the presence of complexing ligand may affect the bioavailability of a drug in blood or tissues, therefore, in order to study the probable interaction of cephradine with antacids all the reaction conditions were simulated to natural environments. Antacids are commonly used in patients complaining of GI irritations. The behavior of cephradine in presence of seven antacids i.e., simethicone, magaldrate, magnesium carbonate, magnesium hydroxide, magnesium trisilicate, sodium bicarbonate and aluminium hydroxide was studied by using standard dissolution apparatus. Cephradine was monitored both by UV and by high performance liquid chromatography. The results revealed that antacids containing polyvalent cations retarded the in vitro availability of cephradine. Moreover, these studies indicated that cephradine was strongly adsorbed on antacids; magnesium trisilicate and simeco® tablets (powdered) exhibited relatively higher adsorption capacities. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Cephradine en_US
dc.subject antacids en_US
dc.subject simethicone en_US
dc.subject magaldrate en_US
dc.subject magnesium carbonate en_US
dc.subject magnesium hydroxide en_US
dc.subject aluminium hydroxide. en_US
dc.subject sodium bicarbonate en_US
dc.subject magnesium trisilicate en_US
dc.title CEPHRADINE ANTACIDS INTERACTION STUDIES en_US
dc.type Article en_US


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