PASTIC Dspace Repository

CARDIOPROTECTIVE EFFECTS AND MECHANISM OF ACTION OF POLYPHENOLS EXTRACTED FROM PROPOLIS AGAINST DOXORUBICIN TOXICITY

Show simple item record

dc.contributor.author ALYANE, M
dc.contributor.author W KEBSA, L BENGUEDOUAR
dc.contributor.author BOUSSENANE, HN
dc.contributor.author ROUIBAH, H
dc.contributor.author LAHOUEL, M
dc.date.accessioned 2022-11-29T05:07:08Z
dc.date.available 2022-11-29T05:07:08Z
dc.date.issued 2008-07-01
dc.identifier.citation Alyane, M., Kebsa, L. B. W., Boussenane, H. N., Rouibah, H., & Lahouel, M. (2008). Cardioprotective effects and mechanism of action of polyphenols extracted from propolis against doxorubicin toxicity. Pakistan Journal of Pharmaceutical Sciences, 21(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14163
dc.description.abstract Propolis is one of the major hive products of bees and is rich in flavonoids, which are known for antioxidant activities. It is well known that the chemical properties of phenolic acids or flavonoids, in terms of the availability of the phenolic hydrogens as hydrogen donating radical scavengers, predict their antioxidant properties. In this study, the flavonoids scavenging activity of propolis has been exploited to obtain protection against the peroxidative damage in rat heart mitochondria which was induced by the administration of an acute dose of doxorubicin (20mg kg−1 , i.p). The peroxidative lesions were evaluated biochemically and iophysically, 24H after DXR administration. Abnormal biochemical changes in heart mitochondria from DXR treated rats including a marked increase in both malondialdehyde (MDA) and anion superoxide production; decrease both of respiratory chain ratio (RCR= V3/V4) and P/O. Pretreatment of rats with propolis extract, given per os (100mg/kg/day) during four days prior to DXR injection, substantially reduced the peroxidative damage in the heart mitochondria: we showed significant reducing both of mitochondrial MDA formation and production of superoxide anion, restoration of RCR and P/O and reducing of rate and the amplitude of mitochondrial swelling. The data demonstrate that antioxidants from natural sources may be useful in the protection of cardiotoxicity in patients who receive doxorubicin and as reported for its claimed beneficial effect on human health by biomedical literature. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Propolis en_US
dc.subject antioxidant en_US
dc.subject flavonoids en_US
dc.subject lipid peroxidation en_US
dc.subject swelling en_US
dc.title CARDIOPROTECTIVE EFFECTS AND MECHANISM OF ACTION OF POLYPHENOLS EXTRACTED FROM PROPOLIS AGAINST DOXORUBICIN TOXICITY en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account