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SELECTION OF STREPTOMYCES ISOLATES FROM TURKISH KARSTIC CAVES AGAINST ANTIBIOTIC RESISTANT MICROORGANISMS

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dc.contributor.author YÜCEL, SEMRA
dc.contributor.author YAMAÇ, MUSTAFA
dc.date.accessioned 2022-11-29T05:07:48Z
dc.date.available 2022-11-29T05:07:48Z
dc.date.issued 2010-01-20
dc.identifier.citation Yücel, S. E. M. R. A., & Yamaç, M. U. S. T. A. F. A. (2010). Selection of Streptomyces isolates from Turkish karstic caves against antibiotic resistant microorganisms. Pak. J. Pharm. Sci, 23(1), 1-6. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14166
dc.description.abstract In this work, actinomycetes isolates were isolated from rock wall and speleothem surfaces and soil samples of 19 karstic caves in Turkey. Out of 290 isolates isolated, 180 isolates (62%) exhibited antimicrobial activity against a panel of four bacteria, two yeasts and four filamentous fungi in the screening program. One of them, Streptomyces sp. 1492, was examined for antibiotic production in batch culture. The maximum of antimicrobial activity was shown at 5th day. Antimicrobial activity of the extracted active compound was recorded as dose dependent bacteriostatic or bactericidal against antibiotic resistant clinical bacteria strains; methicillin-resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterobacter faecium (VRE), and Acinetobacter baumanii. Minimum inhibitor concentration and minimum bactericidal concentrations were determined as lower than standard antibiotic streptomycin; 125 µg/ml and 250-1000 µg/ml, respectively. Active component was found as heat-stable. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Cave en_US
dc.subject Streptomyces en_US
dc.subject antimicrobial activity en_US
dc.title SELECTION OF STREPTOMYCES ISOLATES FROM TURKISH KARSTIC CAVES AGAINST ANTIBIOTIC RESISTANT MICROORGANISMS en_US
dc.type Article en_US


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