Abstract:
The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20mg/Kg body weight
was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance
liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin.
The mean plasma concentration and AUC (0-t) and AUC (0-inf) were significantly different between normal
and dehydrated rabbits (P<0.05), but the absorption rate, distribution rate, and elimination rate did not show
any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the
water-deprived condition.
