PASTIC Dspace Repository

EVALUATION OF ANTIOXIDANT PROPERTIES OF SILYMARIN AND ITS POTENTIAL TO INHIBIT PEROXYL RADICALS IN VITRO

Show simple item record

dc.contributor.author ASGHAR, ZARBAN
dc.contributor.author MASOOD, ZIAEE
dc.date.accessioned 2022-11-29T05:12:57Z
dc.date.available 2022-11-29T05:12:57Z
dc.date.issued 2008-07-08
dc.identifier.citation Asghar, Z., & Masood, Z. (2008). Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro. Pakistan Journal of Pharmaceutical Sciences, 21(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14172
dc.description.abstract Silymarin (milk thistle) has been used for centuries as a natural remedy for diseases of liver and biliary tract. The present study was carried out to evaluate the in vitro free radical scavenging activity and antioxidant properties of silymarin. Antioxidant properties of silymarin were evaluated by four methods: 1) FARP assay for total antioxidant capacity; 2) DPPH radical scavenging assay; 3) the inhibitory effect on RBC hemolysis induced by peroxyl radicals from APPH; 4) the inhibitory effect on plasma oxidation induced by Cu2+. But total phenolic compound was evaluated by Folin-Ciocalteu method. Total polyphenol compounds of silymarin was 0.484±0.017 mg Gallic acid equivalent per mg in comparison to that of green tea which is 0.313±0.095. High Antioxidant properties and significant protective effect of silymarin were in a concentration dependent manner in all methods. Therefore, silymarin is a powerful antioxidant herbal drug which can protect biological systems against the oxidative stress. It is suggested that silymarin may be used in preventing free radical-related diseases as a dietary natural antioxidant supplement. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Botany, Botanical Garden, University of Karachi en_US
dc.subject Silymarin en_US
dc.subject total antioxidant capacity en_US
dc.subject phenolic compounds en_US
dc.title EVALUATION OF ANTIOXIDANT PROPERTIES OF SILYMARIN AND ITS POTENTIAL TO INHIBIT PEROXYL RADICALS IN VITRO en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account