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HEPATOTOXICITY OF CARBON TETRACHLORIDE: PROTECTIVE EFFECT OF GONGRONEMA LATIFOLIUM

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dc.contributor.author OE, ETIM
dc.contributor.author EJ, AKPAN
dc.contributor.author IF, USOH
dc.date.accessioned 2022-11-29T05:16:53Z
dc.date.available 2022-11-29T05:16:53Z
dc.date.issued 2008-07-11
dc.identifier.citation Etim, O. E., Akpan, E. J., & Usoh, I. F. (2008). Hepatotoxicity of carbon tetrachloride: protective effect of Gongronema latifolium. Pakistan journal of pharmaceutical sciences, 21(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14177
dc.description.abstract The protective effect of the ethanolic extract of Gongronema latifolium (GLE) on carbon tetrachloride (CCI4) induced hepatic toxicity was studied. Liver enzymes studied included alanine aminotransferase (ALT), aspartate aminotraferase (AST), and alkaline phosphates (ALP). Hepatic injuries involved with possible necrosis which may have contributed to its possible pathogenesis was explored. Administration of toxicant only showed that the ALT level was significantly (P<0.05) increased to 345.83% when compared to control. Pretreatment with Gongronema latifolium extract (GLE) non-significantly (P<0.05) decreased to 13.08% when compared to those treated with toxicant only. Also under experimental conditions, increasing the concentration of Gongronema latifoluim extract (GLE) non-significantly (P<0.05) decreased dose-dependently the level of ALT to 18.20%. The AST level was non-significantly (P<0.05) increased to 41.55% on treatment with toxicant only. Pretreatment with GLE decreased the AST level non-significantly (P<0.05) to 25.76%. No evident increase or decrease in the level of ALP was observed. Treatments with toxicant showed liver cells filled with uniformly distributed dense small fat droplets, large nuclei, inflamed cells and evidence of necrosis and fibrosis. Pretreatment with 100mg/kg of the extract showed microvesicular fatty change with no evidence of inflammation, necrosis or fibrosis. The protective effect of the GLE was more pronounced in ALT and AST. However, the GLE has a strong modulatory effect against the hepatocellular damage induced by carbon tetrachloride. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Hepatotoxicity en_US
dc.subject G. latifolium en_US
dc.subject modulatory effect en_US
dc.subject carbon tetrachloride en_US
dc.title HEPATOTOXICITY OF CARBON TETRACHLORIDE: PROTECTIVE EFFECT OF GONGRONEMA LATIFOLIUM en_US
dc.type Article en_US


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