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THYMOQUINONE SUPPLEMENTATION AMELIORATES ACUTE ENDOTOXEMIA-INDUCED LIVER DYSFUNCTION IN RATS

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dc.contributor.author HELAL, GOUDA K
dc.date.accessioned 2022-11-29T05:17:21Z
dc.date.available 2022-11-29T05:17:21Z
dc.date.issued 2010-04-02
dc.identifier.citation Helal, G. K. (2010). Thymoquinone supplementation ameliorates acute endotoxemia-induced liver dysfunction in rats. Pakistan journal of pharmaceutical sciences, 23(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14180
dc.description.abstract Endotoxemia caused by lipopolysaccharide (LPS) produced an inflammatory condition contributing to multiple organ failure. This study was carried out to investigate the effects of thymoquinone (TQ), the main constituent of Nigella sativa seeds, against LPS-induced hepatotoxicity. The obtained data revealed that LPS markedly depleted liver reduced glutathione (GSH) and significantly increased the level of malondialdehyde (MDA) and the activity of caspase-3 enzyme in the liver. Serum tumour necrosis factor-alpha (TNF-α) and bilirubin levels and the activities of alkaline phosphatase (ALP) and gamma-glutamyl transferase (γ-GT) enzymes were markedly increased in LPS-treated rats. TQ supplementation resulted in normalization of liver GSH and decreases in the levels of MDA and caspase-3 activity in the liver with reduction of serum TNF-α, serum total bilirubin and the actvities of ALP and γ-GTenzymes. Histopathological examination revealed that TQ administration improved LPS-induced pathological abnormalities in liver tissues. The present study conclude that TQ reduced acute endoxemia-induced liver dysfunction at least in part by its anti-inflammatory, antiapoptotic and antioxidant activities. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Thymoquinone en_US
dc.subject endotoxemia en_US
dc.subject inflammation en_US
dc.subject TNF-α en_US
dc.subject ,oxidative stress en_US
dc.subject liver dysfunction en_US
dc.title THYMOQUINONE SUPPLEMENTATION AMELIORATES ACUTE ENDOTOXEMIA-INDUCED LIVER DYSFUNCTION IN RATS en_US
dc.type Article en_US


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