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TOXIC EFFECTS OF MULTIPLE ANTICANCER DRUGS ON SKIN

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dc.contributor.author KAMIL, NOOR
dc.contributor.author KAMIL, SABA
dc.contributor.author P. AHMED, SHAHIDA
dc.contributor.author ASHRAF, RIZWAN
dc.contributor.author KHURRAM, MOHAMMAD
dc.contributor.author OBAID ALI, MUHAMMAD
dc.date.accessioned 2022-11-29T05:17:58Z
dc.date.available 2022-11-29T05:17:58Z
dc.date.issued 2010-01-20
dc.identifier.citation Kamil, N., Kamil, S., Ahmed, S. P., Ashraf, R., Khurram, M., & Ali, M. O. (2010). Toxic effects of multiple anticancer drugs on skin. Pak J Pharm Sci, 23(1), 7-14. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14183
dc.description.abstract In this study, cutaneous toxicities associated with the administration of chemotherapy in combination are discussed. Rapidly growing cells are the targets of chemotherapy, so the skin, hair follicles, and nail matrix are frequently affected by chemotherapy. Chemotherapy skin reactions are more likely toxic than allergic reactions. There are numerous chemotherapy-induced cutaneous reactions that have been described in the literature. In addition to a variety of miscellaneous reactions, 19 major cutaneous reactions were discussed in current study. This study was designed to evaluate the clinical spectrum of all cutaneous toxicities over two years in hospitalized and ambulatory patients in the Department of Pediatric oncology and to establish probable relationship between the reaction and suspected anticancer protocol with the help of WHO (World Health Organization) Common Toxicity Criteria by Grade. The data on the cutaneous toxicities were analyzed by percentile and ranking method. The minimal (0.8%) cutaneous adverse effects monitored during the study were Petechiae, photosensitivity, pruritis, urticaria, wound-infection, erythema multiforme, hand-foot skin reaction, injection site reaction, dry skin. Alopecia was the single most common (64.3%) adverse effect observed during the study, where as the pigmentary changes were the second most common (18.2%) adverse effect monitored. While these side effects are generally not life threatening, they can be a source of significant distress to patients, especially alopecia. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Anticancer chemotherapy en_US
dc.subject alopecia en_US
dc.subject hyperpigmentation en_US
dc.subject cytotoxicity en_US
dc.subject cutaneous toxicity. en_US
dc.title TOXIC EFFECTS OF MULTIPLE ANTICANCER DRUGS ON SKIN en_US
dc.type Article en_US


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