Abstract:
Tamsulosin hydrochloride is used to treat the symptoms of an enlarged prostate, a condition technically known
as benign prostatic hyperplasia or BPH. The analyte was resolved by using Mobile phase (Potassium
Dihydrogen Orthophosphate and Acetonitrile) at the flow rate of 1.2 Ml/Min. on Isocratic HPLC system
consisting of Jasco Make UV visible Detector of model UV 1575 and Jasco make HPLC pump of model PU
1580. An ODS C- 8 RP Column (4.6mm ID, 250mm L, particle size 5 Micron, at wavelength of 280 Nm. The
linearity range was found to be 0.4 Ml/Ml for Tamsulosin and 0.12 mg/ml to 2.0 mg/ml for its Impurity. The
proposed method is simple, accurate, rapid and selective. Percent Relative standard Deviation was found to be
very low, below 2.0%, which indicates that method is highly precise and specific. Short Analysis time (≤10
min.) coupled with simplicity and ease of operation warrants use of the given method for analysis of
Tamsulosin Hydrochloride along with its impurity as stated above in Bulk. Therefore, method can be useful in
routine Quality Control Analysis in bulk drugs.
