PASTIC Dspace Repository

INTERACTION STUDY BETWEEN LEVOFLOXACIN AND OMEPRAZOLE USING URINARY PHARMACOKINETIC DATA

Show simple item record

dc.contributor.author FARHANA FARUQUEE, CHOWDHURY
dc.contributor.author ULLAH, MD. ASHIK
dc.contributor.author ABUL KALAM AZAD, MOHAMMAD
dc.contributor.author RAYHAN, MD. ISRAT
dc.contributor.author PARVEEN, SEHELI
dc.contributor.author HASNAT, ABUL
dc.date.accessioned 2022-11-29T05:23:20Z
dc.date.available 2022-11-29T05:23:20Z
dc.date.issued 2010-04-04
dc.identifier.citation Faruquee, C. F., Ullah, A., Azad, M. A. K., Rayhan, M. I., Parveen, S., & Hasnat, A. (2010). Interaction study between levofloxacin and omeprazole using urinary pharmacokinetic data. Pak J Pharm Sci, 23(2), 143-148. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14194
dc.description.abstract The objective of this study was to observe the drug interaction between levofloxacin and omeprazole using urinary excretion data. Levofloxacin tablet and omeprazole capsule were administered separately as well as in combination in fasting condition with a wash out period of two weeks after each administration. Urine was collected at different time intervals of 0, 0-2, 2-4, 4-8, 8-12, 12-24, 24-36 and 36-48 hr post-dose and analyzed using a validated HPLC with UV detection. Different pharmacokinetic parameters for both drugs were determined using non-compartmental method. The maximum rate of excretion (Rmax) of levofloxacin was not decreased significantly when co-administered with omeprazole (p>0.05). Similarly no significant difference (p = 0.350) was observed for Rmax of omeprazole when co-administered with levofloxacin. Again the fraction of levofloxacin excreted (fe/f) was not changed significantly (p = 0.953) due to the co-administration of omeprazole. Similarly fraction of omeprazole excreted (fe/f) also remained unaffected (p = 0.672) when coadministered with levofloxacin. No significant change was observed for the area under the rate of excretion versus midpoint of time interval curve from zero to 48 hours (AURC0-48) for levofloxacin and omeprazole (p = 0.816 and 0.792 respectively) when administered separately and co-administered with each other. The study clearly revealed that levofloxacin and omeprazole do not undergo any kind of interactions when administered together. So it can be concluded that these two drugs can be prescribed together to achieve optimum therapeutic activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Drug interaction en_US
dc.subject Levofloxacin en_US
dc.subject Omeprazole en_US
dc.subject Urinary pharmacokinetics en_US
dc.title INTERACTION STUDY BETWEEN LEVOFLOXACIN AND OMEPRAZOLE USING URINARY PHARMACOKINETIC DATA en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account