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DEVELOPMENT OF NEW OPHTHALMIC SUSPENSION PREDNISOLONE ACETATE 1%

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dc.contributor.author AKRAM, MUHAMMAD
dc.contributor.author BAQIR SHYUM NAQVI, SYED
dc.contributor.author GAUHAR, SHAHNAZ
dc.date.accessioned 2022-11-29T05:28:58Z
dc.date.available 2022-11-29T05:28:58Z
dc.date.issued 2010-04-05
dc.identifier.citation Akram, M., Naqvi, S. B. S., & Gauhar, S. (2010). Development of new ophthalmic suspension prednisolone acetate 1%. Pakistan Journal of Pharmaceutical Sciences, 23(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14196
dc.description.abstract Formulation of a new Prednisolone acetate (1%) ophthalmic suspension to obtain a better contactibility of the drug at the site of action. The formulation was evaluated and optimized based on physiological, physicochemical and pharmaceutical parameters and prepared aseptically, keeping particle size between 1-3 µm, while viscosity enhancer, preservative, chelating agent were used to increase the transient residence time, antimicrobial preservation respectively. Isotonicity of the formulation was maintained. Buffering agents used were having buffering capacity NMT 0.05%. pH adjusted at which Prednisolone acetate was stable. The finished product subjected to stress conditions to check the physical stability of the formulation. The formulation was packed in LDPE plastic vials, and subjected to accelerated stability studies at 40o C and the kinetic and predictive method was employed for the determination of degradation rate constant and shelf life. The results showed that the development of a new ophthalmic formulation having significantly better contact time by the selection and optimization of viscosity (HPMC) that obtained (21 cps) with better stability studies. The results concluded that prednisolone acetate 1.0 per cent ophthalmic suspension is more effective than prednisolone phosphate 1.0 per cent ophthalmic solution in suppressing corneal inflammation. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Ophthalmic suspension en_US
dc.subject Prednisolone acetate formulation en_US
dc.subject Formulation development en_US
dc.subject evaluation studies en_US
dc.title DEVELOPMENT OF NEW OPHTHALMIC SUSPENSION PREDNISOLONE ACETATE 1% en_US
dc.type Article en_US


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