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GREEN TEA AMELIORATES RENAL OXIDATIVE DAMAGE INDUCED BY GENTAMICIN IN RATS

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dc.contributor.author ABDEL-RAHEEM, IHAB T
dc.contributor.author A EL-SHERBINY, GAMAL
dc.contributor.author TAYE, ASHRAF
dc.date.accessioned 2022-11-29T05:38:15Z
dc.date.available 2022-11-29T05:38:15Z
dc.date.issued 2010-01-20
dc.identifier.citation Abdel-Raheem, I. T., El-Sherbiny, G. A., & Taye, A. (2010). Green tea ameliorates renal oxidative damage induced by gentamicin in rats. Pak J Pharm Sci, 23(1), 21-28. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14197
dc.description.abstract Recent studies indicate that free radicals are important mediators of renal damage induced by gentamicin (GM), an aminoglycoside antibiotic widely used in treating severe gram-negative infections. Green tea extract (GTE) was reported to have antioxidant and free radical scavenging activities. Therefore, the aim of this work was to investigate the possible protective effect of GTE against gentamicin-induced nephrotoxicity. For this purpose, rats were divided into four groups. Group-1 (control) received normal saline. Group-2 received GTE (300 mg/kg/d, orally). Group-3 received gentamicin (80 mg/kg/d, intraperitoneally). Group-4 was injected with GTE plus gentamicin simultaneously. Daily urinary total protein levels were estimated to assess kidney dysfunction. The rats were sacrificed on the seventh day and kidneys were collected for histopathological studies. Blood urea nitrogen (BUN) and creatinine levels were measured in the blood. Moreover, glutathione (GSH), lipid peroxide expressed as thiobarbituric acid reactive substance (TBARS) levels, superoxide dismutase (SOD) and catalase (CAT) activities were determined in renal tissues. GM produced elevation in urinary total protein, BUN, serum creatinine and TBARS levels. On the other hand, GM reduced the GSH level and SOD, CAT activities. The simultaneous administration of GTE plus gentamicin protected kidney tissues against nephrotoxic effect of gentamicin as evidenced from amelioration of histopathological alterations and normalization of kidney biochemical parameters. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Gentamicin en_US
dc.subject green tea extract en_US
dc.subject nephrotoxicity en_US
dc.subject antioxidant en_US
dc.subject free radicals en_US
dc.subject glutathione en_US
dc.title GREEN TEA AMELIORATES RENAL OXIDATIVE DAMAGE INDUCED BY GENTAMICIN IN RATS en_US
dc.type Article en_US


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