dc.contributor.author |
SEPEHRI, GHOLAMREZA |
|
dc.contributor.author |
SHEIBANI, VAHID |
|
dc.contributor.author |
AZARANG, AFROOZ |
|
dc.contributor.author |
SHAMSIZADEH, ALI |
|
dc.contributor.author |
REZA AFARINESH, MOHAMMAD |
|
dc.contributor.author |
AZIZOLLAHI, SAEED |
|
dc.contributor.author |
SEPEHRI, EHSAN |
|
dc.date.accessioned |
2022-11-29T05:47:23Z |
|
dc.date.available |
2022-11-29T05:47:23Z |
|
dc.date.issued |
2010-04-08 |
|
dc.identifier.citation |
Sepehri, G., Sheibani, V., Azarang, A., Shamsizadeh, A., Afarinesh, M. R., Azizollahi, S., & Sepehri, E. (2010). The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats. Pak J Pharm Sci, 23(2), 170-174. |
en_US |
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14201 |
|
dc.description.abstract |
The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine
administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered
daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7
(0.25, 0.5 and 1 µmol/rat) was injected through ICV. Maximal possible effect percentage (MPE %) was
considered as analgesia index.
Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and
administration of W-7 (0.5 and 1 µmol/rat) decreased the development of tolerance to it.
In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance
which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance
processes. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
en_US |
dc.subject |
Calmodulin inhibitor (W-7) |
en_US |
dc.subject |
morphine tolerance, rat |
en_US |
dc.title |
THE INTRACEREBROVENTRICULAR (ICV) ADMINISTRATION OF W-7, A CALMODULIN INHIBITOR, ATTENUATES THE DEVELOPMENT OF MORPHINE TOLERANCE IN RATS |
en_US |
dc.type |
Article |
en_US |