PASTIC Dspace Repository

THE INTRACEREBROVENTRICULAR (ICV) ADMINISTRATION OF W-7, A CALMODULIN INHIBITOR, ATTENUATES THE DEVELOPMENT OF MORPHINE TOLERANCE IN RATS

Show simple item record

dc.contributor.author SEPEHRI, GHOLAMREZA
dc.contributor.author SHEIBANI, VAHID
dc.contributor.author AZARANG, AFROOZ
dc.contributor.author SHAMSIZADEH, ALI
dc.contributor.author REZA AFARINESH, MOHAMMAD
dc.contributor.author AZIZOLLAHI, SAEED
dc.contributor.author SEPEHRI, EHSAN
dc.date.accessioned 2022-11-29T05:47:23Z
dc.date.available 2022-11-29T05:47:23Z
dc.date.issued 2010-04-08
dc.identifier.citation Sepehri, G., Sheibani, V., Azarang, A., Shamsizadeh, A., Afarinesh, M. R., Azizollahi, S., & Sepehri, E. (2010). The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats. Pak J Pharm Sci, 23(2), 170-174. en_US
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14201
dc.description.abstract The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 (0.25, 0.5 and 1 µmol/rat) was injected through ICV. Maximal possible effect percentage (MPE %) was considered as analgesia index. Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 µmol/rat) decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Calmodulin inhibitor (W-7) en_US
dc.subject morphine tolerance, rat en_US
dc.title THE INTRACEREBROVENTRICULAR (ICV) ADMINISTRATION OF W-7, A CALMODULIN INHIBITOR, ATTENUATES THE DEVELOPMENT OF MORPHINE TOLERANCE IN RATS en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account