Abstract:
The demand for mouth dissolving tablets has been growing during the last decade especially for elderly and
children who have swallowing difficulties. Etoricoxib is a new non-steroidal anti-inflammatory drug (NSAID)
with selective cox-2 inhibitory activity, selective inhibition of cox-2 provides anti-inflammatory and analgesic
activity it is commonly used for osteo-arthritis, rheumatoid arthritis, primary dysmenorrhoea, post operative
dental pain and acute gout. The main criteria for mouth dissolving tablets are to disintegrate or dissolve rapidly
in oral cavity with saliva in 15sec to 60sec with need of water. The disintegrants used should fulfill the criteria
by disintegrating the tablets in specified time limit.in the present investigation variety of super disintegrants like
primogel, kollidone, Ac-Di-sol, L-HPMC, L-HPC, were selected and tablets were prepared by direct
compression method in different concentration like 4% and 8%. The prepared tablets were evaluated for weight
variation, hardness, friability, in vitro disintegration time, wetting time, in vitro dissolution study, etc.
formulation f-9 shows the lowest disintegration time (44sec) and wetting time (52sec). In vitro dissolution
studies revealed that formulation F-9 containning 8% L-HPC showed 97% drug release at the end of 20 min.
