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PRELIMINARY PHARMACOLOGICAL STUDY OF THE PTEROCARPANS MACCKIAN AND TRIFOLIRHIZIN ISOLATED FROM THE ROOTS OF ONONIS VAGINALIS

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dc.contributor.author S, MAGED
dc.contributor.author KADER, ABDEL
dc.date.accessioned 2022-11-29T05:56:11Z
dc.date.available 2022-11-29T05:56:11Z
dc.date.issued 2010-04-11
dc.identifier.citation Abdel-Kader, M. S. (2010). Preliminary pharmacological study of the pterocarpans macckian and trifolirhizin isolated from the roots of Ononis vaginalis. Pakistan Journal of Pharmaceutical Sciences, 23(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14204
dc.description.abstract Preliminary pharmacological study was conducted for the pterocarpans macckian (Mac) and trifolirhizin (Trif). The two compounds isolated from Ononis vaginalis were tested for their hepatoprotective effects against CCl4 induced hepatotoxicity in rats. Activity was accessed by measuring liver enzymes and NP-SH groups. Estrogenic activity was expressed as increase in uterine weight of young female rats. Rat paw edema as a model of acute inflammation induced in Wistar rats using carragenan was used to evaluate the anti-inflammatory activity. Percentage inhibition of the aggregation induced by adenosine diphosphate (ADP) to platelets-rich plasma (PRP) obtained from rats was used as measure for antiplatelet aggregation effect. The aglycone Mac was only more active than the glycoside Trif in the anti-inflammatory assay. It resulted in 65.7% reduction in carregeenan induced rat paw edema compares with 79.8% reduction by indomethacin at the same molar concentration. The activity of Trif was about half of that of silymarin in reducing the elevated levels of liver enzymes at the same molar concentration. About 10 fold molar concentration of Trif produced about half fold increase in uterine weight produced by 17β-estradiol. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Hepatoprotective en_US
dc.subject estrogenic en_US
dc.subject anti-inflammatory en_US
dc.subject antiplatelet aggregation en_US
dc.title PRELIMINARY PHARMACOLOGICAL STUDY OF THE PTEROCARPANS MACCKIAN AND TRIFOLIRHIZIN ISOLATED FROM THE ROOTS OF ONONIS VAGINALIS en_US
dc.type Article en_US


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