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EFFECT OF LITHIUM METAL ON THE CHEMICAL STATUS OF GLUTATHIONE (GSH) PRESENT IN WHOLE BLOOD (ESPECIALLY IN PLASMA AND CYTOSOLIC FRACTION IN HUMAN BLOOD)

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dc.contributor.author KHAN, HAROON
dc.contributor.author UMER JAN, SYED
dc.contributor.author HASHMATULLAH, HASHMATULLAH
dc.contributor.author KHAN, M FARID
dc.contributor.author AHMAD KHAN, KAMRAN
dc.contributor.author UR REHMAN, ASIM
dc.contributor.author WAHAB, ABDUL
dc.date.accessioned 2022-11-29T06:05:11Z
dc.date.available 2022-11-29T06:05:11Z
dc.date.issued 2010-04-12
dc.identifier.citation Khan, H., Jan, S. U., Khan, M. F., Khan, K. A., Rehman, A. U., & Wahab, A. (2010). Effect of lithium metal on the chemical status of glutathione (GSH) present in whole blood (especially in plasma and cytosolic fraction in human blood). Pakistan Journal of Pharmaceutical Sciences, 23(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14205
dc.description.abstract Lithium remains a mainstay in the acute and prophylactic treatment of bipolar affective disorder. It is used in the augmentation of antidepressant treatment and, less frequently, in the augmentation of antipsychotic treatment of schizophrenia. It is reported to have specific anti-suicidal effects. Thus the effect of Lithium was interesting to study on the glutathione (GSH) level in vivo conditions. Ellman’s method has been used to see the effect of lithium on glutathione (GSH) level in whole blood. The time dependent effect of Lithium on the chemical status of glutathione (GSH) was determined in the whole blood (Plasma and cytosolic fraction) of human. The concentration of Glutathione was drastically decreased. The decrease in the glutathione level was concentration and time of interaction dependent, probably due to oxidation of glutathione (GSH) to corresponding disulphide (GSSG). In this paper the effect of Lithium on the Thiol/GSH level was discussed in vitro, which in principal may present a model of in vivo reaction. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Lithium (Li) en_US
dc.subject Reduced Glutathione (GSH) en_US
dc.subject Oxidize Glutathione (GSSG) en_US
dc.subject 5, 5-Dithiobis en_US
dc.subject 2- Nitrobenzoic Acid (DTNB). en_US
dc.title EFFECT OF LITHIUM METAL ON THE CHEMICAL STATUS OF GLUTATHIONE (GSH) PRESENT IN WHOLE BLOOD (ESPECIALLY IN PLASMA AND CYTOSOLIC FRACTION IN HUMAN BLOOD) en_US
dc.type Article en_US


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