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PHARMACODYNAMIC INTERACTION OF GARLIC WITH PROPRANOLOL IN ISCHEMIA-REPERFUSION INDUCED MYOCARDIAL DAMAGE

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dc.contributor.author MOHAMMED, SYED
dc.contributor.author ASDAQ, BASHEERUDDIN
dc.contributor.author INAMDAR, MOHAMMED NASEERUDDIN
dc.contributor.author ASAD, MOHAMMED
dc.date.accessioned 2022-11-29T06:23:19Z
dc.date.available 2022-11-29T06:23:19Z
dc.date.issued 2010-01-20
dc.identifier.citation Asdaq, S. M., Inamdar, M. N., & Asad, M. (2010). Pharmacodynamic interaction of garlic with propranolol in ischemia-reperfusion induced myocardial damage. Pak J Pharm Sci, 23(1), 42-7. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14212
dc.description.abstract The present study was undertaken to explore the interaction of garlic homogenate (GH) with propranolol (PRO) on ischemia-reperfusion injury (IRI) in isolated rat heart preparation. Albino rats were treated with GH at three different doses of 125 mg/kg, (GH-125), 250 mg/kg (GH-250) and 500 mg/kg (GH-500) for 30 days orally. The hearts were excised and mounted on modified Langendorff setup and subjected to 15 min global no flow ischemia and reperfused for 15 min. Pretreatment of animals with PRO, GH-125 and GH-250 (either alone or in combination) provided significant protection to myocardium from IRI damage as indicated by significant decrease in LDH and CK-MB activities in perfusate and an increase in activities of these enzymes in heart tissue homogenate. Similarly, the recovery (%) in developed tension and heart rate were significantly more in treated groups during post-ischemia when compared to control. Moreover, GH-250 either alone or with PRO showed significant increase in activities of antioxidant enzymes such as superoxide dismutase and catalase during IRI damage. However, GH-500 failed to show cardioprotective effect when given alone or along with PRO. These biochemical findings were supported by changes in histopathological studies. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Garlic en_US
dc.subject interaction en_US
dc.subject ischemia-reperfusion en_US
dc.subject isolated heart en_US
dc.subject propranolol en_US
dc.title PHARMACODYNAMIC INTERACTION OF GARLIC WITH PROPRANOLOL IN ISCHEMIA-REPERFUSION INDUCED MYOCARDIAL DAMAGE en_US
dc.type Article en_US


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