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EFFECT OF ETHANOL EXTRACT OF FLOWERS OF VITEX TRIFOLIA LINN. ON CCl4 INDUCED HEPATIC INJURY IN RATS

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dc.contributor.author ANANDAN, RAMASAMY
dc.contributor.author JAYAKAR, BALASUNDARAM
dc.contributor.author KARAR, BIUSAN
dc.contributor.author BABUJI, SEEVALEN
dc.contributor.author MANAVALAN, RAJAPPAN
dc.contributor.author SENTHIL KUMAR, RAJU
dc.date.accessioned 2022-11-29T06:42:38Z
dc.date.available 2022-11-29T06:42:38Z
dc.date.issued 2009-10
dc.identifier.citation Anandan, R., Jayakar, B., Karar, B., Babuji, S., Manavalan, R., & Kumar, R. S. (2009). Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats. Pak. J. Pharm. Sci, 22(4), 391-394. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14217
dc.description.abstract Hepatoprotective activity of ethanolic extract of flowers of Vitex trifolia (Verbenaceae) was studied against CCl4 induced hepatic injury in albino rats. The plant extract (EVT) at the dose of 200 mg/kg, p.o. showed a remarkable hepatoprotective activity. CCl4 induced a significant rise in serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Treatment of rats with EVT significantly (P<0.001) altered serum biomarker enzyme levels to near normal against CCl4 treated rats. The activity of the extract was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Histopathological observations also revealed that treatment with EVT protected the animals from CCl4 induced liver damage. The results indicate that the flowers of V. trifolia possess hepatoprotective activity on CCl4 induced hepatic injury in rats. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Vitex trifolia en_US
dc.subject hepatoprotective en_US
dc.subject carbon tetrachloride en_US
dc.subject biochemical parameters en_US
dc.subject histopathological studies en_US
dc.title EFFECT OF ETHANOL EXTRACT OF FLOWERS OF VITEX TRIFOLIA LINN. ON CCl4 INDUCED HEPATIC INJURY IN RATS en_US
dc.type Article en_US


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