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EVALUATION OF ANTIGLYCOSIDASE AND ANTICHOLINESTERASE ACTIVITIES OF BOEHMERIA NIVEA

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dc.contributor.author SANCHETI, SANDESH
dc.contributor.author SANCHETI, SHRUTI
dc.contributor.author SEO, SUNG-YUM
dc.date.accessioned 2022-11-29T06:48:20Z
dc.date.available 2022-11-29T06:48:20Z
dc.date.issued 2010-04-20
dc.identifier.citation Sancheti, S., Sancheti, S., & Seo, S. Y. (2010). Evaluation of antiglycosidase and anticholinesterase activities of Boehmeria nivea. Pakistan Journal of Pharmaceutical Sciences, 23(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14221
dc.description.abstract In this era, major community worldwide is suffering from diabetes type II, cancer and neurodegenerative disorders. To overcome these diseases, in the screening of Korean medicinal plants, we studied the whole plant of Boehmeria nivea (B. nivea). The methanolic leaf, stem and root extracts of B. nivea and their respective nhexane, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (BuOH) and aqueous fractions were investigated for their total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, α-glucosidase, β-glucosidase, α-galactosidase, β-galactosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme inhibition activities. Profound TPC and DPPH free radical scavenging activities were observed in the EtOAc and BuOH fractions of root, where the BuOH fraction showed high-pitched α-glucosidase inhibition and the EtOAc layer showed the maximum β-glucosidase inhibition. Furthermore, the leaf extract demonstrated the highest β-galactosidase inhibitory activity, but no αgalactosidase inhibition was seen in any of the plant parts. Notable BChE and moderate AChE inhibitory activity was found in whole plant. It can be suggested that whole plant of B. nivea provides a strong biochemical rationale as one of the good choices for the treatment of diabetes type II, cancer and neurodegenerative diseases (AD, etc). en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Boehmeria nivea en_US
dc.subject glycosidase en_US
dc.subject cholinesterase en_US
dc.subject total phenolic content en_US
dc.subject DPPH en_US
dc.title EVALUATION OF ANTIGLYCOSIDASE AND ANTICHOLINESTERASE ACTIVITIES OF BOEHMERIA NIVEA en_US
dc.type Article en_US


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