dc.contributor.author |
REZA HEIDARI, MAHMOUD |
|
dc.contributor.author |
FOROUMADI, ALIREZA |
|
dc.contributor.author |
NOROOZI, HOJAT |
|
dc.contributor.author |
SAMZADEH-KERMANI, ALI |
|
dc.contributor.author |
SARVAR AZIMZADEH, BEHZAD |
|
dc.date.accessioned |
2022-11-29T06:49:29Z |
|
dc.date.available |
2022-11-29T06:49:29Z |
|
dc.date.issued |
2009-10 |
|
dc.identifier.citation |
Heidari, M. R., Foroumadi, A., Noroozi, H., Samzadeh-Kermani, A., & Azimzadeh, B. S. (2009). Study of the anti-inflammatory and analgesic effects of novel rigid benzofuran-3, 4-dihydroxy chalcone by formalin, hot-plate and carrageenan tests in mice. Pak J Pharm Sci, 22(4), 395-401. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14222 |
|
dc.description.abstract |
It is reported that dihydroxy chalcones have analgesic and anti-inflammatory effects. Study of the structure activity relationship (SAR) shows that benzofuran-3-one derivatives may be more effective in this respect. In this study, a new (Z)-2-(3,4- dihydroxybenzylidene)-5-methoxybenzofuran-3(2H)-one (compound 5) was synthesized and its analgesic and anti-inflammatory effects were evaluated by formalin, carrageenan and hotPlate methods in mice. The results showed that, compound 5 induced significant antinociceptive and anti–inflammatory effect (P< 0.01). Maximum analgesia (42.6 %) was obtained at dose of 25 mg/kg in the first phase of formalin test. The effect of compound 5 was higher (87.7%) in chronic phase of inflammation induced by formalin (P< 0.01). Administration of 25 mg/kg of compound 5 inhibited the inflammation induced by carrageenan, 32.8% and 41.7%, 1 and 3 hour after carrageenan injection, respectively. In addition, this dose of compound 5, induces significant analgesia (20.2%) in hot plate test 45 minutes after injection (P<0.01). Therefore it seems that compound 5 has potential for discovery of a compound with potent anti-inflammatory and analgesic effects and its scaffold could be use for further structural modifications. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy, University of Karachi |
en_US |
dc.subject |
Benzylidene benzofuran-3-one |
en_US |
dc.subject |
analgesic activity |
en_US |
dc.subject |
anti-inflammatory effect |
en_US |
dc.subject |
formalin |
en_US |
dc.subject |
carrageenan |
en_US |
dc.subject |
hot-plate |
en_US |
dc.title |
STUDY OF THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF NOVEL RIGID BENZOFURAN-3, 4-DIHYDROXY CHALCONE BY FORMALIN, HOT-PLATE AND CARRAGEENAN TESTS IN MICE |
en_US |
dc.type |
Article |
en_US |