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ORAL GLUCOSE TOLERANCE TEST (OGTT) IN NORMAL CONTROL AND GLUCOSE INDUCED HYPERGLYCEMIC RATS WITH COCCINIA CORDIFOLIA L. AND CATHARANTHUS ROSEUS L.

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dc.contributor.author ISLAM, MD. ARIFUL
dc.contributor.author AKHTAR, MOST. AFIA
dc.contributor.author ISLAM KHAN, MD. RAFIQUL
dc.contributor.author HOSSAIN, MD. SAROWAR
dc.contributor.author ALAM, A. H. M. KHURSHID
dc.contributor.author IMAM IBNE WAHED, MIR
dc.contributor.author AMRAN, MD. SHAH
dc.contributor.author MOKADDESUR RAHMAN, BYTUL
dc.contributor.author AHMED, MARUF
dc.date.accessioned 2022-11-29T06:57:02Z
dc.date.available 2022-11-29T06:57:02Z
dc.date.issued 2009-10
dc.identifier.citation Islam, M. A., Akhtar, M. A., Khan, M. R., Hossain, M. S., Alam, A. H., Ibne-Wahed, M. I., ... & Ahmed, M. (2009). Oral glucose tolerance test (OGTT) in normal control and glucose induced hyperglycemic rats with Coccinia cordifolia L. and Catharanthus roseus L. Pakistan Journal of Pharmaceutical Sciences, 22(4), 402-404. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14223
dc.description.abstract The aim of this study is to investigate the hypoglycemic effects of petroleum ether, chloroform and ethyl acetate fractions isolated from ethanolic extracts of Coccinia cordifolia and Catharanthus roseus on normal control and orally glucose-induced hyperglycemic rats. Single doses (150 mg/kg) of different fractions of C. cordifolia and C. roseus extracts were intraperitonelly administered. The serum blood glucose level was obtained by pricking the tail vein using glucometer at time 0, 30, 60, 90, 150 and 270 minutes. In the orally glucose induced hyperglycemic rats, chloroform-coccinia (CHCl3-CC) fraction showed maximum reduction of blood glucose level by 21.94% on 60 minute of the experiment. On the other hand maximum reduction (p<0.05) of 17.92% was observed for petroleum ether-catharanthus (PET-CR) on 30 minute of the experiment. Metformin HCl was used as standard drug. Our results indicate that the CHCl3-CC fraction is relatively more potent than other fractions of C. cordifolia. Similarly the PET-CR is found to be better than other fractions of catharanthus. Phytochemical screening test results showed that chloroform fraction of C. cordifolia contain saponins and flavonoids compounds, which are known to be hypoglycemic. On the other hand petroleum ether fraction of C. roseus contains tannins, flavonoids and alkaloid compounds produced varying degree of blood sugar reduction. On the pharmacological point of view C. cordifolia and C. roseus appears to be a valuable plant, which can be useful, at least as an adjunct, in the therapy of diabetes. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Coccinia cordifolia en_US
dc.subject Catharanthus roseus en_US
dc.subject OGTT en_US
dc.subject metformin en_US
dc.subject hyperglycemic rats en_US
dc.title ORAL GLUCOSE TOLERANCE TEST (OGTT) IN NORMAL CONTROL AND GLUCOSE INDUCED HYPERGLYCEMIC RATS WITH COCCINIA CORDIFOLIA L. AND CATHARANTHUS ROSEUS L. en_US
dc.type Article en_US


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