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IMMUNOMODULATORY EFFECTS OF ZERUMBONE ISOLATED FROM ROOTS OF ZINGIBER ZERUMBET

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dc.contributor.author KEONG, YEAP SWEE
dc.contributor.author BANU ALITHEEN, NOORJAHAN
dc.contributor.author MUSTAFA, SHUHAIMI
dc.contributor.author ABDUL AZIZ, SURAINI
dc.contributor.author ABDUL RAHMAN, MASHITOH
dc.contributor.author MANAF ALI, ABDUL
dc.date.accessioned 2022-11-29T08:50:10Z
dc.date.available 2022-11-29T08:50:10Z
dc.date.issued 2010-01-20
dc.identifier.citation Keong, Y. S., Alitheen, N. B., Mustafa, S., Aziz, S. A., Rahman, M. A., & Ali, A. M. (2010). Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. Pak J Pharm Sci, 23(1), 75-82. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14229
dc.description.abstract In this study, the immunomodulatory effects of zerumbone isolated from Zingiber zerumbet were investigated by evaluating the effects of this compound towards the lymphocytes proliferation (mice thymocytes, mice splenocytes and human human peripheral blood mononuclear cells, PBMC), cell cycle progression and cytokine (interleukin 2 and 12) induction. Lymphocyte proliferation assay showed that zerumbone was able to activate mice thymocytes, splenocytes and PBMC at dosage dependent pattern where the best concentration was 7.5 µg/mL. Flow cytometry analysis showed the highest population of PBMC entered into G2/M phase after treatment for 72 h with 7.5 µg/mL zerumbone. The production of human interleukin-2 and human interleukin12 cytokines in culture supernatant from zerumbone activated lymphocytes was prominently upregulated at 24 hour and decreased from 48 h to 72 h. The above results indicate that zerumbone can be used as immunomodulatory agent which can react toward the immune cell cytokine production in dosage dependent pattern. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Zingiber zerumbet en_US
dc.subject zerumbone en_US
dc.subject immunomodulation en_US
dc.subject interleukin 2 en_US
dc.title IMMUNOMODULATORY EFFECTS OF ZERUMBONE ISOLATED FROM ROOTS OF ZINGIBER ZERUMBET en_US
dc.type Article en_US


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