Volume 24: Recent submissions

  • ANTIOXIDANT ACTIVITY OF COVOLVULUS HYSTRIX VAHL AND ITS CHEMICAL CONSTITUENTS 
    DONIA, ABD EL RAHEIM MOHAMMED; ALQASOUMI, SALEH IBRAHIM; AWAAD, AMANI SHAFEEK; CRACKER, LYLE (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-08)
    Total alcohol and successive extracts (diethyl ether, chloroform, ethyl acetate and n-butanol) of Covolvulus hystrix Vahl were screened for their antioxidant activity using free radical 2-2- diphenyl-1-picrylhydrazyl (DPPH) ...
  • HEPATOPROTECTIVE STUDIES ON HALOXYLON SALICORNICUM: A PLANT FROM CHOLISTAN DESERT 
    MAHMOOD AHMAD; SOFIA ERAM (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    The objective was to study the in-vivo hepatoprotective effect of aerial parts of Haloxylon salicornicum (Moq.) Bunge (Family: Chenopodiaceae) in order to validate its traditional use in hepatobiliary disorders, by ...
  • PRODUCTION OF ACTEOSIDE FROM CISTANCHE TUBULOSA BY β-GLUCOSIDASE 
    ZHAO, SHU-YAN; HE, XIU-YAN; JIA, BAO-GUO; PENG, QING-YUN; LIU, XIN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-07)
    Acteoside and echinacoside are the major active components of Herba Cistanches. Facilitated β-glucosidation was investigated as a means of increasing harvest of acteoside from Cistanche tubulosa. Fresh Cistanche tubulosa ...
  • PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF ANNONA SQUAMOSA LINN IN ISONIAZID-RIFAMPICIN INDUCED HEPATOTOXICITY IN RATS 
    MOHAMED SALEEM THATTAKUDIAN SHEIK UDUMAN; RAMKANTH SUNDARAPANDIAN; AZAGUSUNDHARAM MUTHUMANIKKAM; KALIMUTHU, GNANAPRAKASH; PARAMESWARI S, ANGALA; SRINIVAS, THIRUVENGADA RAJAN VASANTHI; KARUNAKARAN, GAUTHAMAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-06)
    The present study was made to investigate the protective effect of methanolic extract of Annona squamosa on isoniazid-rifampicin-induced hepatotoxicity in rats. Rats were divided into five different groups (n=6), group ...
  • FLAVONOIDS OF ENHYDRA FLUCTUANS EXHIBITS ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY IN DIFFERENT ANIMAL MODELS 
    SANTANU SANNIGRAHI; MAZUMDER, UPAL KANTI; DILIPKUMAR PAL; SILPI LIPSA MISHRA; SUBHASIS MAITY (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Enhydra fluctuans (Compositae), an edible semi aquatic herbaceous vegetable plant, widely used in traditional system of Indian medicine. Total flavonoids of E. fluctuans (TFEF) were screened for analgesic and antiinflammatory ...
  • THE PROTECTIVE ROLE OF GLUTATHIONE IN SILVER INDUCED TOXICITY IN BLOOD COMPONENTS 
    KHAN, HAROON; KHAN, MUHAMMAD FARID; ASIM-UR-REHMAN; SYED UMER JAN; NASEEM ULLAH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-05)
    Silver Nitrate (AgNo3) effect on the status of reduced glutathione (GSH), the major non-protein thiol in blood components were examined using freshly isolated plasma and cytosolic fraction of whole blood of healthy human ...
  • INTESTINAL PERMEABILITY STUDIES OF SULPIRIDE INCORPORATED INTO SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) 
    CHITNENI, MALLIKARJUN; KOK KHIANG PEH; YUSRIDA DARWIS; MUTHANNA ABDULKARIM; GHASSAN ZUHAIR ABDULLAH; QURESHI, MOHAMMED JAVED (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-04)
    The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability ...
  • EFFECTS OF AEGELINE, A MAIN ALKALOID OF AEGLE MARMELOS CORREA LEAVES, ON THE HISTAMINE RELEASE FROM MAST CELLS 
    NUGROHO, AGUNG ENDRO; SUGENG RIYANTO; SUKARI, MOHAMAD ASPOLLAH; KAZUTAKA MAEYAMA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Aegeline or N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from Aegle marmelos Correa collected in Yogyakarta Indonesia. In our study, we investigated the effects of aegeline on ...
  • SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SCHIFF BASES OF [4-(AMINO) -5- PHENYL- 4H-1, 2, 4-TRIAZOLE- 3- THIOL] 
    JUBIE, SELVARAJ; PRANABESH SIKDAR; ANTONY, SHANISH; KALIRAJAN, RAJAGOPAL; GOWRAMMA, BYRAN; GOMATHY, SUBRAMANIAN; ELANGO, KANNAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-03)
    The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using water as solvent under reflux condition for 3-4 h. The compound ...
  • SECONDARY DEFENSE ANTIOXIDANT STATUS OF VITAMIN C, VITAMIN E AND GSH IN MALARIA, CAUSED BY PLASMODIUM FALCIPARUM AND PLASMODIUM VIVAX 
    TARIQ JAVEED; TARIQ JAVEED; KHAN, IKRAMULLAH; KHAN, MUHAMMAD KHALID (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-02)
    Present investigations focused on the antioxidant defense in malaria caused by plasmodium Falciparum and plasmodium Vivax the mean ±SEM values of Vitamin C, Vitamin E and GSH very highly significantly decreased as compared ...
  • DETERMINATION OF TOXIC METALS IN SOME HERBAL DRUGS THROUGH ATOMIC ABSORPTION SPECTROSCOPY 
    BUSHRA HINA; RIZWANI, GHAZALA HAFEEZ; SHAHID NASEEM (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    This study presents a picture of occurrence of heavy metals (Pb, Cd, Cu, Cr, Co, Fe, Ni, Zn) in some selected valuable herbal drugs (G. glabra, O. bracteatum, V. odorata , F. vulgare, C. cyminum, C. sativum, and ...
  • ROLE OF CHLAMYDIA PNEUMONIAE, HELICOBACTER PYLORI AND CYTOMEGALOVIRUS IN CORONARY ARTERY DISEASE 
    ABDULLAH AL-GHAMDI; ASIF AHMED JIMAN-FATANI; HASSAN EL-BANNA (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-01)
    Coronary artery disease (CAD) is the leading cause of death in many countries. The underlying mechanism of the chronic inflammatory process in atherosclerosis is still unknown. As a possible trigger, different viruses ...
  • PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT AND ANTIBACTERIAL EFFECTS OF SEA BUCKTHORN BERRIES 
    SAADIA CHAMAN; SYED, NAWAZISH-I-HUSAIN; ZEESHAN DANISH; KHAN, FARRAKH ZIA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Sea buckthorn berries are therapeutically used as folk medicine for a variety of diseases, however, the scientific evidence is hardly available to support their role. This study explored their chemical constituents and ...
  • INTERACTION STUDY OF MOXIFLOXACIN AND LOMEFLOXACIN WITH CO-ADMINISTERED DRUGS 
    GANDHIMATHI MURUGANATHAN; NAIR, DHANYA KONDAYIL; NATARAJAN BHARATHI; RAVI, THENGUNGAL KOCHUPAPY (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Moxifloxacin and lomefloxacin are fluoroquinolone antibiotics used in treating urinary and respiratory tract infections. Fluoroquinolones are known to have interactions with drugs that are active in gastro intestinal tract. ...
  • ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF DIFFERENT FRACTIONS OF COCCINIA CORDIFOLIA L. ON NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS 
    MD. ARIFUL ISLAM; KHAN, RAFIQUL ISLAM; SAROWAR HOSSAIN; KHURSHID ALAM; IMAM IBNE WAHED; BYTUL M. RAHMAN; ASM ANISUZZAMAN; SHARIF MD. SHAHEEN (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    The present study was carried out to observe the antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of Coccinia cordifolia ...
  • PHARMACOLOGICAL PROFILE OF SALVADORA PERSICA 
    MANSOOR AHMAD; HINA IMRAN; ZAHRA YAQEEN; ZAKIR-UR REHMAN; ATIQ-UR-RAHMAN; NUDRAT FATIMA; TEHMINA SOHAIL (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    This work was conducted to investigate the various pharmacological activities of Salvadora. persica family Salvadoracea and that includes anti inflammatory, analgesic, CNS, bleeding and clotting time activity by ...
  • EFFECTS OF APOMORPHINE ON LOCOMOTIVE ACTIVITY AND MONOAMINE METABOLISM: A DOSE RELATED STUDY 
    HUMA IKRAM; SHOAIB AHMAD; HALEEM, DARAKHSHAN JABEEN (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    We have monitored dose dependent effects of apomorphine on motor activity and monoamine metabolism. Behavioral sensitization and craving, which develop upon repeated treatment with dopamine receptor agonist apomorphine, ...
  • EVALUATION OF CEFACLOR ORAL SUSPENSIONS STABILITY USING REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND ANTIMICROBIAL DIFFUSION METHODS 
    TARAWNEH, KHALED AHMAD; HALASAH, ZINA ATALLAH; KHLEIFAT, ALI MOHMAD; BATARSEH, MUFEED ISSA; KHLEIFAT, KHALED MOHMAD; AL-MUSTAFA, AHMED HUSSEIN (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    The effect of temperature stresses on Cefaclor suspensions under different storage conditions for a duration of 14 days was tested. The degradation of Cefaclor was determined on the 2nd, 7th and 14th day after reconstitution ...
  • EVALUATION OF PHYTOCONSTITUENTS AND ANTI-NEPHROTOXIC AND ANTIOXIDANT ACTIVITIES OF MONOCHORIA VAGINALIS 
    SUBRAMANI PALANI; SUNDARARAJAN RAJA; KUMAR, RAMANUJAM PRAVEEN; RANGANATHAN SELVARAJ; KUMAR, BALASUBRAMANIAN SENTHIL (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Monochoria vaginalis is an herbaceous medicinal plant used to treat, liver problems India. Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and ...
  • NUTRIENT COMPOSITION, PHENOLIC CONTENT AND FREE RADICAL SCAVENGING ACTIVITY OF SOME UNCOMMON VEGETABLES OF PAKISTAN 
    KHATTAK, KHANZADI FATIMA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Vegetables play a vital role in the prevention of human disease and in the improvement of general health as these contain vitamins, amino acids, fiber, antioxidants and minerals. In the present study, some less ...

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