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Browsing Issue 02 by Issue Date

Browsing Issue 02 by Issue Date

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  • ROLE OF CHLAMYDIA PNEUMONIAE, HELICOBACTER PYLORI AND CYTOMEGALOVIRUS IN CORONARY ARTERY DISEASE 
    ABDULLAH AL-GHAMDI; ASIF AHMED JIMAN-FATANI; HASSAN EL-BANNA (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-01)
    Coronary artery disease (CAD) is the leading cause of death in many countries. The underlying mechanism of the chronic inflammatory process in atherosclerosis is still unknown. As a possible trigger, different viruses ...
  • SECONDARY DEFENSE ANTIOXIDANT STATUS OF VITAMIN C, VITAMIN E AND GSH IN MALARIA, CAUSED BY PLASMODIUM FALCIPARUM AND PLASMODIUM VIVAX 
    TARIQ JAVEED; TARIQ JAVEED; KHAN, IKRAMULLAH; KHAN, MUHAMMAD KHALID (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-02)
    Present investigations focused on the antioxidant defense in malaria caused by plasmodium Falciparum and plasmodium Vivax the mean ±SEM values of Vitamin C, Vitamin E and GSH very highly significantly decreased as compared ...
  • SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SCHIFF BASES OF [4-(AMINO) -5- PHENYL- 4H-1, 2, 4-TRIAZOLE- 3- THIOL] 
    JUBIE, SELVARAJ; PRANABESH SIKDAR; ANTONY, SHANISH; KALIRAJAN, RAJAGOPAL; GOWRAMMA, BYRAN; GOMATHY, SUBRAMANIAN; ELANGO, KANNAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-03)
    The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using water as solvent under reflux condition for 3-4 h. The compound ...
  • INTESTINAL PERMEABILITY STUDIES OF SULPIRIDE INCORPORATED INTO SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) 
    CHITNENI, MALLIKARJUN; KOK KHIANG PEH; YUSRIDA DARWIS; MUTHANNA ABDULKARIM; GHASSAN ZUHAIR ABDULLAH; QURESHI, MOHAMMED JAVED (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-04)
    The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability ...
  • THE PROTECTIVE ROLE OF GLUTATHIONE IN SILVER INDUCED TOXICITY IN BLOOD COMPONENTS 
    KHAN, HAROON; KHAN, MUHAMMAD FARID; ASIM-UR-REHMAN; SYED UMER JAN; NASEEM ULLAH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-05)
    Silver Nitrate (AgNo3) effect on the status of reduced glutathione (GSH), the major non-protein thiol in blood components were examined using freshly isolated plasma and cytosolic fraction of whole blood of healthy human ...
  • PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF ANNONA SQUAMOSA LINN IN ISONIAZID-RIFAMPICIN INDUCED HEPATOTOXICITY IN RATS 
    MOHAMED SALEEM THATTAKUDIAN SHEIK UDUMAN; RAMKANTH SUNDARAPANDIAN; AZAGUSUNDHARAM MUTHUMANIKKAM; KALIMUTHU, GNANAPRAKASH; PARAMESWARI S, ANGALA; SRINIVAS, THIRUVENGADA RAJAN VASANTHI; KARUNAKARAN, GAUTHAMAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-06)
    The present study was made to investigate the protective effect of methanolic extract of Annona squamosa on isoniazid-rifampicin-induced hepatotoxicity in rats. Rats were divided into five different groups (n=6), group ...
  • PRODUCTION OF ACTEOSIDE FROM CISTANCHE TUBULOSA BY β-GLUCOSIDASE 
    ZHAO, SHU-YAN; HE, XIU-YAN; JIA, BAO-GUO; PENG, QING-YUN; LIU, XIN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-07)
    Acteoside and echinacoside are the major active components of Herba Cistanches. Facilitated β-glucosidation was investigated as a means of increasing harvest of acteoside from Cistanche tubulosa. Fresh Cistanche tubulosa ...
  • ANTIOXIDANT ACTIVITY OF COVOLVULUS HYSTRIX VAHL AND ITS CHEMICAL CONSTITUENTS 
    DONIA, ABD EL RAHEIM MOHAMMED; ALQASOUMI, SALEH IBRAHIM; AWAAD, AMANI SHAFEEK; CRACKER, LYLE (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-08)
    Total alcohol and successive extracts (diethyl ether, chloroform, ethyl acetate and n-butanol) of Covolvulus hystrix Vahl were screened for their antioxidant activity using free radical 2-2- diphenyl-1-picrylhydrazyl (DPPH) ...
  • MODIFIED PICRATE METHOD FOR DETERMINATION OF CYANIDE IN BLOOD 
    MUHAMMAD AVAIS; KHAN, MUHAMMAD SARWAR; KHAN, MUHAMMAD ARIF; KAMRAN ASHRAF; AMAR NASIR; MASOOD RABBANI; ABU SAEED HASHMI (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-09)
    Cyanide (CNֿ) is widely distributed in the ecosystem and has been associated with toxic effects in humans and animals. Most outbreaks of CNֿ poisoning in animals result from ingestion of plants containing cyanogenic glycosides. ...
  • PREPARATION, IN-VITRO AND IN-VIVO CHARACTERIZATION OF TRANSDERMAL PATCH CONTAINING GLIBENCLAMIDE AND ATENOLOL: A COMBINATIONAL APPROACH 
    ANITHA, POSINA; RAMKANTH, SUNDARAPANDIYAN; MOHAMED T S SALEEM; UMASANKARI, KOMMIREDDY; REDDY, BODDU PRAVEEN; CHETTY, MADHUSUDHANA (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-10)
    A novel aspiration in treatment of chronic disease like diabetes associated with other non communicable disease risk factors, such as hypertension is to provide greater therapeutic effect, overcome the side effects by ...
  • LICHENS AS POSSIBLE SOURCES OF ANTIOXIDANTS 
    KOSANIĆ, MARIJANA; RANKOVIĆ, BRANISLAV (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-11)
    Acetone, methanol and aqueous extracts of the lichen Cetraria islandica, Lecanora atra, Parmelia pertusa, Pseudoevernia furfuraceae and Umbilicaria cylindrica were investigated for antioxidant activity by five different ...
  • ANTISPASMODIC ACTIVITY OF TEUCRIUM STOCKSIANUM BOISS. 
    NIAZ ALI; SYED WADOOD ALI SHAH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-12)
    The aim of the study was to explore the traditional antispasmodic use of Teucrium stocksianum on scientific grounds, and preliminary screen the specie for phytochemical constituents. Crude methanolic extract of aerial parts ...
  • ANTAGONISTIC BACTERIA FROM LIVE CORALS, TUTICORIN COASTAL WATERS, SOUTHEASTERN INDIA 
    CHELLARAM, CHINNACHAMY; SREENIVASAN, SUBRAMANI; ANAND, THANKAPPAN PREM; KUMARAN, SEKARGOUNDER; KESAVAN, DHAMODARAN; PRIYA, GOVINDARAJAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-13)
    The objective of this study is to isolate and production of secondary metabolites with bioactive substances by coral reef (Acropora formosa and Favia palida) associated bacteria was carried out from the Tuticorin ...
  • INVESTIGATING THE IN VITRO DRUG RELEASE KINETICS FROM CONTROLLED RELEASE DICLOFENAC POTASSIUM-ETHOCEL MATRIX TABLETS AND THE INFLUENCE OF CO-EXCIPIENTS ON DRUG RELEASE PATTERNS 
    SHEFAAT ULLAH SHAH; KIFAYAT ULLAH SHAH; ASIMUR REHMAN; KHAN, GUL MAJID (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-14)
    The objective of the study was to formulate and evaluate controlled release polymeric tablets of Diclofenac Potassium for the release rate, release patterns and the mechanism involved in the release process of the drug. ...
  • ANTI DIABETIC EFFECT OF ACHYRANTHES RUBROFUSCA LEAF EXTRACTS ON ALLOXAN INDUCED DIABETIC RATS 
    GEETHA, GOVINDARAJULU; GOPINATHAPILLAI, PRASANTH KALAVALARASARIEL; SANKAR, VEINDRAMUTHU (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-15)
    The aqueous and ethanolic extracts of Achyranthes rubrofuca leaves (AR) were studied for their hypoglycemic activity. Thirty animals were taken and they were divided into five groups. First group acts as control, remaining ...
  • ANTIDIARRHOEAL AND ANTIULCER ACTIVITIES OF HIPPOCRATEA AFRICANA ROOT EXTRACT 
    OKOKON, JUDE EFIOM; AKPAN, HENRY DAN; UMOH, EMEM EKPO; EKAIDEM, ITEMOBONG SUNDAY (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-16)
    The effect of ethanol root extract of H. africana on experimentally induced diarrhoea and ulcer was studied in rodents. The extract (200 – 600mg/kg) considerably inhibited castor oil induced diarrhoea, small intestine transit ...
  • STEROID SENSITIVE NEPHROTIC SYNDROME IN PAEDIATRICS 
    SYEDA JAVARIA NADIR; NAZISH SALEEM; FATIMA AMIN; KHAWAJA TAHIR MAHMOOD (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-17)
    Nephrotic syndrome is basically a set of signs or symptoms that may point to kidney problems, a condition when large amounts of protein leak out into the urine. In children protein excretion greater than 40 mg/m2 .hr-1 ...
  • DESIGN AND EVALUATION OF A NEW FORMULATION OF ENALAPRIL MALEATE TABLET 
    REHANA BIBI; BAQIR SHYUM NAQVI; MUHAMMAD HARRIS SHOAIB; NAJIA RAHIM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-18)
    Enalapril maleate, one of the Angiotensin converting enzyme (ACE) inhibitor is effective in the treatment of hypertension. Enalapril maleate is selected for the present study. The aim of this study was to develop a ...
  • SERUM ESTROGEN AND INTERLEUKIN-6 LEVELS IN POSTMENOPAUSAL FEMALE OSTEOARTHRITIS PATIENTS 
    SADIA AFZAL; AZIZA KHANAM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-19)
    The objective of the present study is to determine whether the levels of endogenous estrogen and interleukin-6 (IL-6) are associated with osteoarthritis (OA) in postmenopausal women. Forty-three patients who were suffering ...
  • REPORT IN VIVO ANTIOXIDANT ACTIVITY OF ZATARIA MULTIFLORA BOISS ESSENTIAL OIL 
    FARIBA SHARIFIFAR; AMIN DERAKHSHANFAR; DEHGHAN-NUDEH, GHOLAMREZA; ABBASI, NAJMA; ABBASI, REZA; GHARAEI, REZA REZAEI; KOOHPAYEH, ABED; DANESHPAJOUH, MOHAMMAD (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-20)
    Zataria multiflora Boiss. (Lamiaceae) is an endemic plant to Iran with many traditional uses. We have reported previously in vitro antioxidant activity of the essential oil of the plant. In the present work we aimed to ...

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