• REVIEW TRPC signaling mechanisms and therapeutic opportunities: Trapdoors are monitored by gatekeepers 

  Ammad Ahmad Farooqi; Asma M Riaz; Shahzad Bhatti (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-31)

  This Review summarizes our current state of knowledge of the functional role of TRPC channels in health and disease, with particular emphasis on current advancements in the field. Additionally, this review provides an ...
• Review on the demographic and social impact of methadonemedication therapy on Malaysian patients 

  Mohamed Mansor Manan; Salmiah Mohd Ali; Khan, Muhammad Anwar Nawab; Sara Jafarian; Mohammed Abdul Hameed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-30)

  This study is an observational cross-sectional study aimed to examine the possible demographic and social characteristics of patients enrolled at the Methadone Maintenance Therapy Adherence Clinic (MMTAC) in Malaysia. ...
• REVIEW Making personalized prostate cancer medicine a reality: Challenges and opportunities in the re-establishment of gold standards 

  Ammad Ahmad Farooqi; Ghazala Butt; Gohar Yousaf; Muhammad Imran Qadir; Uzma Shaukat; Qaisar Mansoor; Madeeha Awan; Shahzad Bhatti; Almas Begum (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-29)

  Prostate cancer is a serious multidimensional disorder that arises because of misrepresentation of signaling cascades and acquired resistance against apoptosis. It is progressively becoming more insurmountable because ...
• REPORT Antibacterial activity of local herbs collected from Murree (Pakistan) against multi-drug resistant Klebsiella pneumonae, E. coli and methyciline resistant Staphylococcus aureus 

  Qaisar Mansoor; Saira Shaheen; Uzma Javed; Uzma Shaheen; Irum Iqrar; Muhammad Ismail (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-28)

  Exploring healing power in plants emerged in prehistory of human civilization. Sustaining good health has been achieved over the millions of years by use of plant products in various traditional sockets. A major contribution ...
• REPORT Significance of herbal medicine in removing excessive iron content in human 

  Wan Mohd Azhar bin Wan Ibrahim; Eraj Humayun Mirza; Syed Fahad Akbar Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-27)

  Heavy metals in cigarette tobacco such as iron may cause a serious damage on human health. Surveys showed that the accumulation of certain toxic heavy metals like cadmium, mercury, iron is very often due to the effect of ...
• REPORT Impact of herbal drug combination on lipid profile, renal and cardiac parameters 

  Zeeshan Feroz; Khan, Rafeeq Alam; Amber; Mahayrookh (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-26)

  For the past two decades, there has been an increasing interest in the investigation of medicinal plants as potential sources of new therapeutic agents; hence it is crucial to recognize the apparent toxicity that might ...
• Assessment of CYP2B6 activity in rats: A cocktail study with bupropion alone and in combined with tolbutamide 

  Xu, Ren-ai; Hu, Lufeng; Wang, Zhe; Du, Xiaoxiang; Zhu, Haiyan; Zhang, Xiuhua (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-25)

  A “cocktail”of numerous probe drugs to assess the metabolic activity of the corresponding cytochrome P450 enzymes requires that there is no problem of interaction among them. Some interactions among probe drugs can appear ...
• Anti-inflammatory and gastroprotective activities of the aqueous extract of Micromeria fruticosa (L.) Druce ssp Serpyllifolia in mice 

  Abu-Gharbieh, Eman; Shehab, Naglaa Gamil; Khan, Saeed Ahmed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-23)

  Micromeria fruticosa is used widely in many Mediterranean regions for various inflammatory conditions. The aim of this work was to assess the anti-inflammatory and gastroprotective activities of the aqueous extract of ...
• Optimization of growth conditions for the isolation of dextran producing Leuconostoc spp. from indigenous food sources 

  Farwa Sarwat; Nuzhat Ahmed; Afsheen Aman; Shah Ali Ul Qader (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-22)

  Leuconostoc are known to produce dextran, which have great commercial importance in chemical, medical and food industry. The present study is an attempt to select the best medium for the isolation of indigenous dextran ...
• Screening of Bunium bulbocastanum for antibacterial, antifungal, phytotoxic and haemagglutination activities 

  Khan, Ibrar; Haroon Ahmad; Nasir Ali; Bashir Ahmad; Hamid Tanoli (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-21)

  The current study was aimed at screening the Bunium bulbocastanum for its antibacterial, antifungal, phytotoxic and haemagglutination activities.The crude methanolic extract and n-hexane fraction showed significant (89%) ...
• Preparation and evaluation of lipid vesicles of camptothecin as targeted drug delivery system 

  Prabhakara, Prabhu; Zenia, Teles; Marina, Koland; Shama, Khandige Prasanna; Girish, Shetty Nisha; Matapady, Nairy Harish (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-20)

  Site-specific delivery of anticancer based therapy of human cancers has led to several remarkable outcomes, particularly in the therapy of breast cancer and lymphoma. Camptothecin, a plant secondary metabolite is widely ...
• Adrenaline improves endurance of rabbit gastrocnemius: A study with continuous high frequency stimulation 

  Syed Mudassir Haider Rizvi; Muhammad Abdul Azeem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-19)

  Beta adrenoceptor agonists are well known for their potentiating effects on peak twitch and tetanic tension and defatiguing effects on skeletal muscles. Adrenaline (ADR) is one of these agonist which is known for inotropism ...
• A model portraying experimental loss of hair cell: The use of distortion product otoacoustic emission in the assessment of rat’s ear 

  Behzad Mesbahzadeh; Mohammad Ajalloueyan; Gholam Reza Kaka; Alireza Askari; Hasanalifard, Mahdieh (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-18)

  The use of rats in research academies to study deafness is widespread, meanwhile medicinal methods to eliminate hair cells is also increasing. Thus, aminoglycosides and loop diuretics have grasped more attention. This ...
• The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice Chuan Zhou1 , Youfei Shi1 

  Zhou, Chuan; Shi, Youfei; Li, Jinlian; Zhang, Wen; Fu, Changqi; Wang, Yanmin; Liu, Yan; Liu, Jianzhu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-17)

  The present study prepared the pulmonary fibrosis model in mice by using Bleomycin and carry out the investigations on the effects of taurochenodeoxycholic acid (TCDCA) in preventing pulmonary fibrosis in mice. Expression ...
• Comparison of chemical composition of Aerva javanica seed essential oils obtained by different extraction methods 

  Muhammad Qasim Samejo; Shahabuddin Memon; Muhammad Iqbal Bhanger; Khan, Khalid Mohammed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-16)

  Aerva javanica (Burm.f.) Juss. ex Schult. seed essential oils were obtained by hydrodistillation (HD) and dry steam distillation (SD) extracting methods and analyzed by using gas chromatography-mass spectrometry(GC-MS). ...
• Phytochemical, antimicrobial, insecticidal and brine shrimp lethality bioassay of the crude methanolic extract of Ajuga parviflora Benth 

  Najmur Rahman; Mansoor Ahmad; Muhammad Riaz; Mehjabeen; Noor Jahan; Rizwan Ahmad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-15)

  Methanolic extract of medicinal herb Ajuga parviflora Benth. was evaluated for phytochemical screening (the plant extract showed the presence of aromatic compounds, carbohydrates, glycosides, tannins, alkaloids, polyphenols, ...
• 3-[(2-chloroquinolin-3-yl)methyl]quinazolin-4(3H)-ones as potential larvicidal agents 

  Roopan, Selvaraj Mohana; Khan, Fazlur-Rahman Nawaz; Jin, Jong Sung (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-14)

  The larvicidal effect of series of 3-[(2-chloroquinolin-3-yl)methyl]quinazolin-4(3H)-ones, 5a-e, against Chironomus tentans Fabricius has been investigated. The results showed that tested compounds demonstrated strong ...
• Synthesis, conjugation and evaluation of some novel polymers and their micro particles for sustained release drug formulations 

  Syed Umer Jan; Khan, Gul Majid; Izhar Hussain; Gaskell, Elsie E; Hutcheon, Gillian H (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-13)

  To prepare and evaluate three novels functionalized polymers (PGA, PGA-co-caprolactone & PGA-copentadecalactone) for the development of nanoparticles which were further used in the development of a novel polymeric prodrug ...
• Truncated Type II isopentenyl diphosphate isomerase from hyperthermophilic Achaeon Thermococcus kodakaraensis implicates the necessity of its N-terminal amino acid residues in protein thermostability 

  Masood Ahmed Siddiqui; Naeem Rashid; Habib-ur-Rehman (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-12)

  The enzyme isopentenyl diphosphate isomerase (IDI, EC 5.3.3.2) interconverts isopentenyl diphosphate and dimethylallyl diphosphate. We had previously cloned Tk-idi gene encoding the thermostable Tk-IDI enzyme from ...
• The effect of high-fructose intake on the vasopressor response to angiotensin II and adrenergic agonists in Sprague-Dawley rats 

  Mohammed Hadi Abdulla; Munavvar Abdul Sattar; Nor Azizan Abdullah; Johns, Edward James (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-11)

  Effect of losartan was assessed on systemic haemodynamic responses to angiotensin II (Ang II) and adrenergic agonists in the model of high-fructose-fed rat. Twenty-four Sprague-Dawley (SD) rats were fed for 8 weeks either ...

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