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MOLYBDENUM HYDROXYLASE SUPER FAMILY SHOWS CIRCADIAN ACTIVITY FLUCTUATION IN MICE LIVER: EMPHASIS ON ALDEHYDE HYDROXYLASE AND XANTHINE OXIDASE

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dc.contributor.author AHMED AL-ABBASI, FAHAD
dc.contributor.author IBRAHEEM AL-SIENI, ABDULBASIT
dc.date.accessioned 2022-11-30T08:58:35Z
dc.date.available 2022-11-30T08:58:35Z
dc.date.issued 2010-10-01
dc.identifier.citation Al-Abbasi, F. A., & Al-Sieni, A. (2010). Molybdenum hydroxylase super family shows circadian activity fluctuation in mice liver: emphasis on aldehyde hydroxylase and xanthine oxidase. Pak J Pharm Sci, 23(4), 359-362. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14256
dc.description.abstract Non-CYP oxidase enzymes are important system in biotransformation of drugs and environmental pollutants. Molybdenum containing oxidase enzymes such as aldehyde oxidase and xanthine oxidase are constitutive tissue enzymes that metabolize several drug moieties. Herein, we evaluated the circadian rhythm of these two enzymes in mice liver using different substrate/oxygen donor couples. Aldehyde oxidase showed typical rhythmic fluctuation with peak activity at night cycle and minimum activity at light cycle using pthalazine/ferricyanide and 3-methylisoquinoline/ferricyanide substrates. On the other hand, xanthine oxidase showed interrupted diurnal rhythm, however peak and minimum enzyme activities were similar to aldehyde oxidase circadian rhythm. In conclusion, diurnal rhythm of both molybdenum hydroxylase enzymes was confirmed and validated in mice liver tissue that might provide further insights in the experimental evaluation of phase-I pharmacokinetics for new drugs. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Molybdenum hydroxylase en_US
dc.subject aldehyde oxidase en_US
dc.subject xanthine oxidase en_US
dc.subject diurnal rhythm en_US
dc.title MOLYBDENUM HYDROXYLASE SUPER FAMILY SHOWS CIRCADIAN ACTIVITY FLUCTUATION IN MICE LIVER: EMPHASIS ON ALDEHYDE HYDROXYLASE AND XANTHINE OXIDASE en_US
dc.type Article en_US


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