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TIME-DEPENDENT CHANGES OF IMMUNOLOGIC RESPONSES AFTER BURN INJURY AND IMMUNOMODULATION BY CIMETIDINE AND PYRIMETHAMINE IN AN ANIMAL MODEL

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dc.contributor.author A, JAFARZADEH
dc.contributor.author ZM, HASSAN
dc.contributor.author M, EBTEKAR
dc.contributor.author MOHAGHEGH-HAZRATI S
dc.contributor.author T, TIRAIHI
dc.date.accessioned 2022-11-30T09:06:43Z
dc.date.available 2022-11-30T09:06:43Z
dc.date.issued 2010-10-03
dc.identifier.citation Jafarzadeh, A., Hassan, Z. M., Ebtekar, M., Mohaghegh-Hazrati, S., & Tiraihi, T. (2010). Time-dependent changes of immunologic responses after burn injury and immunomodulation by cimetidine and pyrimethamine in an animal model. Pakistan Journal of Pharmaceutical Sciences, 23(4), 367-374. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14258
dc.description.abstract Severe suppression of the immune system is the major cause of infections following burn injury. The aim of this study was to investigate the time-related alterations of immune responses following thermal injury in an animal model and also to modulate immune responses by use of the immunomdulators cimetidine and pyrimethamine. Male Balb/c mice were anesthetized and given a 10% total body surface area full-thickness burn. The timedependent changes of delayed type hypersensitivity (DTH) and antibody responses to sheep red blood cell (SRBC) were assessed at post-burn days (PBD). The effects of different doses of cimetidine and pyrimethamine on DTH response were also quantitated at 10 PBD. Marked suppression of DTH response occurred during 30 days after burn trauma, with maximal suppression occurring between 10 to 14 days after burn injury. Simultaneously the antibody response to SRBC was significantly increased after thermal trauma. Cimetidine (at doses of 10 and 15 mg/kg) and pyrimethamine (at doses of 5 and 10 mg/kg) significantly augmented DTH response after thermal injury. These results showed that the severe time-dependent alterations occurred in DTH and antibody responses following burn injury. Cimetidine and pyrimethamine also restore burn-induced suppression of DTH response following thermal trauma. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Burn en_US
dc.subject delayed type hypersensitivity en_US
dc.subject antibody response en_US
dc.subject cimetidine en_US
dc.subject pyrimethamine en_US
dc.subject immunosuppression en_US
dc.subject immunomodulation, animal model en_US
dc.title TIME-DEPENDENT CHANGES OF IMMUNOLOGIC RESPONSES AFTER BURN INJURY AND IMMUNOMODULATION BY CIMETIDINE AND PYRIMETHAMINE IN AN ANIMAL MODEL en_US
dc.type Article en_US


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