Abstract:
A versatile, accurate, precise and economic method for simultaneous determination of simvastatin and
ezetimibe in fixed dose combination products was developed. The absorbance values at 236 nm and 234 nm of over line spectrum was used for the estimation of simvastatin and ezetimibe, respectively without mutual
interference. This method obeyed Beer’s law in the concentration range of 4 – 16 µg /ml for simvastatin and 4-
16 µg /ml for ezetimibe. The results of analyses have been validated statistically for linearity, accuracy and
precision of the proposed method.
