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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETERIC METHOD FOR SIMULTANEOUS DETERMINATION OF SIMVASTATIN AND EZETIMIBE IN TABLET FORMULATIONS

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dc.contributor.author BALAJI, S
dc.contributor.author SUNITHA, A
dc.date.accessioned 2022-11-30T09:09:33Z
dc.date.available 2022-11-30T09:09:33Z
dc.date.issued 2010-10-04
dc.identifier.citation Balaji, S., & Sunitha, A. (2010). Development and validation of spectrophotometeric method for simultaneous determination of simvastatin and ezetimibe in tablet formulations. Pakistan Journal of Pharmaceutical Sciences, 23(4), 375-379. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14259
dc.description.abstract A versatile, accurate, precise and economic method for simultaneous determination of simvastatin and ezetimibe in fixed dose combination products was developed. The absorbance values at 236 nm and 234 nm of over line spectrum was used for the estimation of simvastatin and ezetimibe, respectively without mutual interference. This method obeyed Beer’s law in the concentration range of 4 – 16 µg /ml for simvastatin and 4- 16 µg /ml for ezetimibe. The results of analyses have been validated statistically for linearity, accuracy and precision of the proposed method. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Simvastatin (SMV) en_US
dc.subject Ezetimibe (EZE) en_US
dc.subject methanol en_US
dc.subject ultraviolet spectrophotometry en_US
dc.subject absorption ratio method en_US
dc.title DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETERIC METHOD FOR SIMULTANEOUS DETERMINATION OF SIMVASTATIN AND EZETIMIBE IN TABLET FORMULATIONS en_US
dc.type Article en_US


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