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A STEREOLOGICAL STUDY OF EFFECTS OF AQUEOUS EXTRACT OF TAMARINDUS INDICA SEEDS ON PANCREATIC ISLETS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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dc.contributor.author MAHMOUDZADEH-SAGHEB, HAMIDREZA
dc.contributor.author HEIDARI, ZAHRA
dc.contributor.author SHAHRAKI, MOHAMMADREZA
dc.contributor.author MOUDI, BITA
dc.date.accessioned 2022-11-30T09:51:14Z
dc.date.available 2022-11-30T09:51:14Z
dc.date.issued 2010-10-13
dc.identifier.citation Mahmoudzadeh-Sagheb, H., Heidari, Z., Shahraki, M., & Moudi, B. (2010). A stereological study of effects of aqueous extract of Tamarindus indica seeds on pancreatic islets in streptozotocin-induced diabetic rats. Pak J Pharm Sci, 23, 427-34. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14268
dc.description.abstract Tamarindus indica Linn was used as a traditional medicine for the management of diabetes mellitus in human and experimental animals. This study investigated effects of aqueous extract of Tamarindus indica seeds (AETIS) against STZ-induced damages in pancreatic islands by means of stereological methods. sixty matured normoglycemic male Wistar rats, weighing 200- 250 gr, were selected and randomly divided into 6 groups (n=10). Control, STZ-induced diabetic; by intraperitoneal injection of 55 mg/Kg streptozotocin, Treated control group (TC); received AETIS at a dose of 200mg/kg/day, and AETIS treated diabetic groups (TD1-3); received respectively AETIS at the dose of 50, 100,and 200 mg/kg/day by gavage from one week after induction of diabetes by STZ. After 8 weeks of experiment, stereological estimation of volume density and total volume of islets and beta cells, volume weighted mean islets volume, mass of beta cells, islets, and pancreas and total number of islets were done. Volume density and total volume of islets, volume weighted mean islets volume, volume density islets/pancreas, volume density beta cells/islet, mass of islets and pancreas of treated diabetic groups (TD1-3) were significantly higher than untreated diabetic group (P<0.001), and in TD3 group these values were comparable to controls. Although total volume and mass of beta cells in TD1-3 were significantly higher than D group but they were significantly lower than control group (P<0.05). Total number of islets, pancreas wet weight and volume did not show any significant changes between control and experimental groups (P>0.05). Results suggested that AETIS partially restores pancreatic beta cells and repairs STZ- induced damages in rats. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Diabetes mellitus en_US
dc.subject Tamarindus indica en_US
dc.subject stereology en_US
dc.subject beta cell en_US
dc.title A STEREOLOGICAL STUDY OF EFFECTS OF AQUEOUS EXTRACT OF TAMARINDUS INDICA SEEDS ON PANCREATIC ISLETS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS en_US
dc.type Article en_US


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