dc.contributor.author |
M, SARASWATHI |
|
dc.contributor.author |
RM, ROHINI |
|
dc.contributor.author |
RANAPRATHAPSINGH, RANAPRATHAPSINGH |
|
dc.contributor.author |
NAYEEM, NAIRA |
|
dc.date.accessioned |
2022-11-30T10:09:21Z |
|
dc.date.available |
2022-11-30T10:09:21Z |
|
dc.date.issued |
2010-10-18 |
|
dc.identifier.citation |
RM, R., & Naira, N. (2010). Synthesis and evaluation of mannich bases of benzimidazo [1, 2-c] quinazolin-6 [5h]-thione for antimicrobial activity. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14273 |
|
dc.description.abstract |
The intermediate Benzimidazo[1,2-c] quinazolin-6(5H)-thione (1) was obtained by cyclization of 2-(2’-
aminophenyl) benzimidazole with carbon disulfide. Mannich base (2a-d) of compound (1) was obtained on
treatment with Para formaldehyde and secondary aliphatic amines, similarly treatment of (1) with different
ketones afforded respective mannich bases (3 e-h). All derivatives synthesized were characterized from IR and 1 HNMR spectral data’s. Moderate anti bacterial activity was exhibited from 2a-d and from 3f, 3h against S.
aureus, E. coli, and E. fecalis but very negligent activity were seen from these compounds when screened
against P aeruginosa |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
en_US |
dc.subject |
Mannich base |
en_US |
dc.subject |
Benzimidazo [1,2-c] quinazoline–6(5H)-thione |
en_US |
dc.subject |
antimicrobial activity |
en_US |
dc.title |
SYNTHESIS AND EVALUATION OF MANNICH BASES OF BENZIMIDAZO [1,2-C] QUINAZOLIN- 6(5H)-THIONE FOR ANTIMICROBIAL ACTIVITY |
en_US |
dc.type |
Article |
en_US |