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SYNTHESIS AND EVALUATION OF MANNICH BASES OF BENZIMIDAZO [1,2-C] QUINAZOLIN- 6(5H)-THIONE FOR ANTIMICROBIAL ACTIVITY

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dc.contributor.author M, SARASWATHI
dc.contributor.author RM, ROHINI
dc.contributor.author RANAPRATHAPSINGH, RANAPRATHAPSINGH
dc.contributor.author NAYEEM, NAIRA
dc.date.accessioned 2022-11-30T10:09:21Z
dc.date.available 2022-11-30T10:09:21Z
dc.date.issued 2010-10-18
dc.identifier.citation RM, R., & Naira, N. (2010). Synthesis and evaluation of mannich bases of benzimidazo [1, 2-c] quinazolin-6 [5h]-thione for antimicrobial activity. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14273
dc.description.abstract The intermediate Benzimidazo[1,2-c] quinazolin-6(5H)-thione (1) was obtained by cyclization of 2-(2’- aminophenyl) benzimidazole with carbon disulfide. Mannich base (2a-d) of compound (1) was obtained on treatment with Para formaldehyde and secondary aliphatic amines, similarly treatment of (1) with different ketones afforded respective mannich bases (3 e-h). All derivatives synthesized were characterized from IR and 1 HNMR spectral data’s. Moderate anti bacterial activity was exhibited from 2a-d and from 3f, 3h against S. aureus, E. coli, and E. fecalis but very negligent activity were seen from these compounds when screened against P aeruginosa en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Mannich base en_US
dc.subject Benzimidazo [1,2-c] quinazoline–6(5H)-thione en_US
dc.subject antimicrobial activity en_US
dc.title SYNTHESIS AND EVALUATION OF MANNICH BASES OF BENZIMIDAZO [1,2-C] QUINAZOLIN- 6(5H)-THIONE FOR ANTIMICROBIAL ACTIVITY en_US
dc.type Article en_US


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