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Browsing No.6 (Supplementary), November 2017 by Issue Date

Browsing No.6 (Supplementary), November 2017 by Issue Date

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  • Cross-linked guar gum and sodium borate based microspheres as colon-targeted anticancer drug delivery systems for 5-fluorouracil 
    Kamal, Tehsin; Sarfraz, Muhammad; Arafat, Mosab; Mikov, Momir; Rahman, Nisar-ur (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-01)
    The aim was to prepare cross linked polymer of 5-fluorouracil loaded microspheres containing guar gum and sodium borate for colon-targeted drug delivery systems. Micro spheres were prepared using emulsification cross ...
  • Larvicidal, pupicidal and adulticidal activities of non-polar solvent extract of Cymbopogon nardus (Linn.) whole plant against a mosquito, Culex quinquefasciatus (Say.) 
    Ilahi, Ikram; Yousafzai, Ali Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-02)
    The present research is aimed to investigate the susceptibility of Cx. quinquefasciatus larvae (2nd and 4th instars), pupae and adults during exposure to various concentrations of C. nardus n-hexane extract. Increase in ...
  • Development and validation of stability indicating assay method for cinitapride in bulk & tablets 
    Rehman, Atta-ur; Beg, Anwar Ejaz; Bushra, Rabia; Ashfaq, Maria; Zafar, Farya; Ali, Huma; Rizvi, Mehwish (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-03)
    A simple stability indicating UV-spectrophotometric method has been developed and validated for the determination of cinitapride hydrogen tartrate (CHT) in bulk and solid pharmaceutical dosage form. Drug absorption was ...
  • Radiolabeling of benzylpenicillin with lutetium-177: Quality control and biodistribution study to develop theranostic infection imaging agent 
    Shahzad, Muhammad Adeel; Naqvi, Syed Ali Raza; Rasheed, Rashid; Yameen, Muhammad; Anjum, Fozia; Ahmed, Muhammad Tauqeer; Hussain, Zaib; Gillani, Syed Jawad Hussain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-04)
    Benzylpenicillin acts through binding with beta-lactamase enzyme and inhibiting the bacterial cell wall biosynthesis. Therefore, the radiolabeling of benzylpenicillin with lutetium-177 is expected to serve as a theranostic ...
  • Chromatographic method development and validation for the determination of valsartan in biological fluid 
    Ghayas, Sana; Shoaib, Muhammad Harris; Siddiqui, Fahad; Yousuf, Rabia Ismail; Masood, M. Ali; Anjum, Fakhsheena; Bushra, Rabia; Bashir, Lubna; Naz, Shazia; Muhammad, Iyad Naeem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-05)
    A swift, precise and simple HPLC bioanalytical technique with UV detection was established and validated for quantitative estimation of valsartan in human plasma. The analyte was separated from plasma by protein precipitation ...
  • The hepatoprotective effects of aquatic extract of Levisticum officinale against paraquat hepatocyte toxicity 
    Afarnegan, Hasan; Shahraki, Ali; Shahraki, Jafar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-06)
    Paraquat is extensively used as a strong nitrogen-based herbicide for controlling weeds in agriculture. This herbicide is extremely toxic to humans and induces multiorgan failure due to accumulation in the cells. So far, ...
  • HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves 
    Maddisetty, PN Prasad; Doss, VA; S, Mohanasundaram; V, Srinivasarao; T, Mohanbabu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-07)
    In this study, we have aimed to analyze the phytochemical composition of this plant and the concentration of strychnine and brucine. The identification of bioactive compounds was done by GC-MS with NIST Library. Strychnine ...
  • Enriched environment palliates nicotine-induced addiction and associated neurobehavioral deficits in rats 
    Nawaz, Amber; Batool, Zehra; Ahmed, Saara; Tabassum, Saiqa; Khaliq, Saima; Mehdi, Bushra Jabeen; Sajid, Irfan; Ahmad, Shoaib; Saleem, Sadia; Naqvi, Fizza; Naqvi, Faizan; Haider, Saida (Enriched environment palliates nicotine-induced addiction and associated neurobehavioral deficits in rats, 2017-11-08)
    This study was designed to investigate the role of enriched environment in preventing and/or reducing the neurobehavioral deficits produced after nicotine administration in albino Wistar rats. Equal numbers of rat in two ...
  • Sorafenib tosylate, Ribavirn and Sofosbuvir combination therapy for HCV virus infected patients with decompensated liver cancer 
    Munir, Bushra; Ahmed, Bilal; Kiran, Shumaila; Jalal, Fatima; Zahoor, Muhammad Kashif; Shehzadi, Saba; Oranab, Sadaf; Kamran, Sayed Kashif Shahid; Ghaffar, Abdul (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-09)
    : Hepatitis C is the most common health problem worldwide and is major cause of death due to proliferation of hepatocellular carcinoma. The medicines available for HCV treatment overcome up-to 95% complications of HCV. ...
  • Biologically active compounds from the red sea sponge Suberea sp. 
    Shaala, Lamiaa A; Almohammadi, Ameen (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-10)
    Investigation of the cytotoxic fraction of the extracts of the Red Sea sponge Suberea sp. resulted in the identification of two new compounds, 1-(hydroxy(1H-pyrrol-2-yl)methyl)guanidine and 4-(2-amino-3-methylbut-3-en-1-yl)phenol ...
  • Isolation and characterization of antibiotic producing bacterial strains from red soil of Himalayan region of Pakistan 
    Uzair, Bushra; Firdous, Neelam; Khan, Barkat Ali; Khan, Samiullah; Fatima, Sammer; Kausar, Rehana; Bano, Asma (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-11)
    The emergence of multi drug resistant microbial pathogens has become a global health challenge and set a dire requirement of searching new effective antimicrobials. Soil is an ultimate reservoir of biologically active micro ...
  • Metal complexes of isonicotinylhydrazide and their antitubercular activity 
    Ali, Mohsin; Ahmed, Mansoor; Hafiz, Saleem; Kamal, Mustafa; Mumtaz, Majid; Hanif, Muhammad; Khan, Khalid Mohammed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-12)
    The development and spreading of Multi Drug Resistant TB strains is hampering endeavours for the control and administration of tuberculosis (TB). The expansion episodes of multi-medication safe strains of Mycobacterium ...
  • The role of Glutathione, Cysteine and D-Penicillamine in exchanging Palladium and Vanadium metals from albumin metal complex 
    Mukhtiar, Muhammad; Jan, Syed Umer; Ullah, Ihsan; Hussain, Abid; Ullah, Izhar; Gul, Rahman; Ali, Essa; Jabbar, Abdul; Kuthu, Zulfiqar Hussan; Wasim, Muhammad; Khan, Muhammad Farid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-13)
    Thiol groups are extensively present across biological systems being found in range of small molecules (e.g. Glutathione, Homo-cysteine) and proteins (e.g. albumin, haemo-globin). Albumin is considered to be a major thiol ...
  • Cytotoxic and acute toxicity studies of isoniazid derivatives 
    Naeem, Sabahat; Akhtar, Shamim; Lei, Zi-Ning; Lu, Kimberly; Zafar, Shaista; Ahmed, Ahsaan; Ali, Mohsin; Ahmed, Mansoor; Chen, Zhe-Sheng (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-14)
    Cancer is ultimately the result of cells that hysterically grow and do not die. Cells can experience uncontrolled growth if there are mutations to DNA, and therefore, alterations to the genes involved in cell division. ...
  • MRSA: Prevalence and susceptibility pattern in health care setups of Karachi 
    Siddiqui, Tuba; Muhammad, Iyad Naeem; Khan, Muhammad Naseem; Naz, Shazia; Bashir, Lubna; Sarosh, Nosheen; Masood, Rida; Ali, Aatka; Fatima, Sakina; Naqvi, Talat (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-15)
    This assessment aims to determine the prevalence of methicillin resistance and multidrug resistance (MDR) among the clinical isolates of Staphylococcus aureus and antimicrobial susceptibility profile of methicillin resistant ...
  • Dizocilpine induced psychosis-like behavior in rats: A possible animal model with full spectrum of schizophrenia 
    Shahzad, Sidrah; Ahmad, Saara; Madiha, Syeda; Khaliq, Saima; Liaquat, Laraib; Sadir, Sadia; Rafiq, Sahar; Tabassum, Saiqa; Batool, Zehra; Haider, Saida (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-16)
    Schizophrenia (SZ) is categorized as neuropsychiatric disorder with reduced lifespan and significant impairments in social and vocational functioning. One of the best proposed pharmacological animal models is dizocilpine, ...
  • Notch1 signaling activation protected myocardium against hypoxia injury via reducing programmed cell death 
    Hu, Yongjun; Zheng, Zhaofen; Pan, Hongwei; Peng, Jianqiang; Luo, Yangping; Cui, Bo; Zhong, Xin (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-17)
    Programmed cell death plays an important role in cardio protection, and Notch1 was an important factor related to programmed cell death. The role of Notch1 on ischemia myocardium remains unclear.H9C2 myocardial cells were ...
  • Pharmacokinetic behavior of montelukast in indigenous healthy male volunteers 
    Fayyaz, Amtul; Khan, Junaid Ali; Ashraf, Muhammad Mudassar; Akhter, Naheed; Aslam, Bilal; Khalid, Muhammad Fiaz; Altaf, Sidra; Naseer, Rana Dawood; Akram, Muhammad; Shah, Syed Muhammad Ali; Khadam, Muhammad Waqas; Tahir, Imtiaz Mahmood (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-18)
    Aim of present study was to investigate the pharmacokinetic behavior of Montelukast in the healthy male volunteers under indigenous conditions. One tablet of montelukast 10 mg was administered in each subject and blood ...

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