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Browsing Volume 27 by Title

Browsing Volume 27 by Title

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  • Effect and mechanism of miRNA to osteosarcoma cell 
    Tian, Ke; Wang, Limin; Di, Ruiqing; Xu, Jianzhong; Li, Guangheng; Li, Zhifu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-11)
    MicroRNA has proved to be low expression in many tumor cells. In addition, it was also proved that as a kind of cancer suppressor gene, miR-199a-3p in miRNA can affect the growth and invasion ability of tumor cells. This ...
  • Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats 
    Noor Aisyah Ismail; Nor Syafawati Shamsahal Din; Siti Syariah Mamat; Zalina Zabidi; Wan Noraziemah Wan Zainulddin; Farah Hidayah Kamisan; Farhana Yahya; Norhafizah Mohtarrudin; Mohd Nasir Mohd Desa; Zainul Amiruddin Zakaria (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-13)
    The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups ...
  • Effect of deprotenizing agent and quantification of donepezil hydrochloride in human plasma 
    Liew, Kai Bin; Peh, Kok Khiang; Fung Tan, Yvonne Tze (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    The effect of deprotenizing agents on recovery of donepezil hydrochloride in the development of a simple, rapid, selective and sensitive high performance liquid chromatography method for quantification of donepezil hydrochloride ...
  • The effect of enzyme digestion time on the detection of diatom species 
    Yu, Zhengliang; Liu, Chao; Wang, Huijun; Chen, Ling; Hu, Sunlin; Zhao, Jian; Wang, Huipin; Zhou, Yu; Xie, Weibing (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-05-12)
    This study is aimed at detecting diatom in lung, liver and kidney tissues using PCR - DHPLC technology after different periods of enzyme digestion to assess the effect of enzyme digestion on the detection of diatom species. ...
  • Effect of Lactobacillus species on Streptococcus mutans Biofilm formation 
    Ayaz Ahmed; Wu Dachang; Zhou Lei; Liu Jianjun; Qiu Juanjuan; Xin Yi (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-18)
    Streptococcus mutans is the primary pathogen responsible for initiating dental caries and decay. The presence of sucrose, stimulates S. mutans to produce insoluble glucans to form oral biofilm also known as dental plaque ...
  • Effect of leaf extracts of Taraxacum officinale on CCl4 induced Hepatotoxicity in rats, in vivo study 
    Muhammad Gulfraz; Dawood Ahamd; Muhammad Sheeraz Ahmad; Rehmatullah Qureshi; Raja Tahir Mahmood; Nyla Jabeen; Kashif Sarfraz Abbasi (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-12)
    Taraxacum officinale L is a medicinal plant, which has enormous medicinal values against various types of liver disorders and it has traditionally been used for the treatment of liver problems by people from the South ...
  • The effectiveness of isometric exercises as compared to general exercises in the management of chronic non-specific neck pain 
    Muhammad Khan; Rabail Rani Soomro; Syed Shahzad Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-22)
    To evaluate the effectiveness of isometric exercises as compared to general exercises in chronic non-specific neck pain. For this randomised controlled trial total 68 patients (34 each group) with chronic non-specific ...
  • Effects of Cleome viscosa on hyperalgesia, oxidative stress and lipid profile in STZ induced diabetic neuropathy in Wistar rats 
    Rao, Boddapati Srinivasa; Reddy, Kasala Eshvendar; Kumar Parveen; Narendra, Bodduluru Lakshmi; Shekhar, Sriram Chandra; Lahkar Mangala (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    Diabetes mellitus is a severe devastating epidemic has an effect on both developing and developed countries. Diabetic neuropathy (DN) is a secondary microvascular complication of diabetes causing damage to the nerves and ...
  • The effects of intellan and cytacon on hematological and biochemical parameter in rabbits: A comparative study 
    Humera Anser; Raheela Najam; Khan, Saira Saeed; Bushra Riaz; Sana Sarfaraz (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    Several plants have been selected based on their use in traditional systems of medicine, and research has identified a number of natural compounds that could act as Nootropicagents. In this study a herbal product Intellan ...
  • Effects of intravenous bolus injection of emulsified isoflurane on QTc interval of healthy volunteers in Pharmacokinetics study 
    Rong Liu; Yan Li; Jin Liu; Zhang, Wen-Sheng; Yi, Xiao-Qian; Jing XU (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    Emulsified isoflurane is a novel intravenous anesthetic, which is a lipid emulsion of isoflurane. As some drugs have a QTc-prolongation effect which can increase a risk of arrhythmia, this study was to evaluate the effects ...
  • Effects of probiotics on the growth performance and intestinal micro flora of broiler chickens 
    Li, Yin-bo; Xu, Qian-qian; Yang, Cun-jin; Yang, Xin; Lv, Le; Yin, Chun-hua; Liu, Xiao-lu; Yan, Hai (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-05-17)
    Antibiotics have been used in poultry industry for decades to promote growth and protect animals from diseases, followed by various side effects. In efforts of searching for a better alternative, probiotic is of extensive ...
  • Effects of various excipients on tizanidine hydrochloride tablets prepared by direct compression 
    Khan, Lubna Ghazal; Nighat Razvi; Fakhsheena Anjum; Siddiqui, Saeed Ahmed; Sana Ghayas (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    This study was conducted to assess the effects of various excipients in 10 different Tizanidine hydrochloride tablet dosage forms that were prepared by direct compression method (DC). Various excipients are available for ...
  • Enhanced production of maltase (α-glucosidase) from newly isolated strain of Bacillus licheniformis KIBGE-IB4 
    Muhmmad Asif Nawaz; Zainab Bibi; Afsheen Aman; Raheela Rahmat Zohra; Shah Ali Ul Qader (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-06)
    Maltase (alpha-glucosidase) hydrolyzes α-(1→4) glucosidic bond of maltose into two glucose molecules. It is widely used in various foods, beverages and also in textile and biofuel industries. During current study, ...
  • Enumeration of CD4+ CD25+ T regulatory cells in Type-II diabetes retinopathy 
    Nadeem Afzal; Khursheed Javaid; Shakeela Zaman; Abu Zafar; Abdul H Nagi (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    Diabetes mellitus (DM) is a health concern because it leads to complications such as retinopathy. Pakistan has 6.9 million DM affected people that will be doubled by 2025. A study was designed to enumerate CD4+ CD25+ ...
  • Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical 
    Muhammad Khalid; Tanveer Hussain Bokhari; Mushtaq Ahmad; Haq Nawaz Bhatti; Munawar Iqbal; Abdul Ghaffar; Muhammad Imran Qadir (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-10)
    The optimum conditions to label ethylenediaminetetramethylene phosphonate (EDTMP) compound with 90y as a potential candidate for bone metastases therapy were investigated. Yttrium-90 is a pure β-emitter and can be obtained ...
  • Evaluation of nutritional and sub-acute toxicological study of plant based supplement of Achyranthes aspera 
    Nudrat Fatima; Nabeela G Dar; Hina Imran; Tehmina Sohail; Uzma Asghar; Zahra Yaqeen; Shazia Syed; Khalid Jamil (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    The present study was conducted for the nutritional, microbiological and toxicological evaluation of test compound having main ingredient Achyranthes aspera. Nutritional value assessment, microbiological analysis and ...
  • Experimental research on the effect of mitomycin C fibrin gel on spinal peridural scar tissue in rats 
    Liu, Wenping (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-15)
    This paper aimed to study the best working concentration of mitomycin C (MMC) fibrin gel on spinal peridural scar tissue in rats and the sustained release function of peridural adhesion after laminectomy of rats. 96 SD ...
  • Expression of trehalose synthase gene from Pseudomonas putida P06 in Pichia pastoris 
    Tengfei, Wang; Dai, Kun; Jia, Shiru (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-05-07)
    The trehalose synthase (TreS) gene from Pseudomonas putida P06 was successfully ligated with pPICZaA expression vector by the EcoRI and XbaI and was transformed into Pichia pastoris GS115 by electrotransformation. The ...
  • Formulation and bioequivalence of two Valsartan/Amlodipine Immediate release tablets after a single oral administration 
    Abdel Naser Zaid; Salam Natur; Aiman Qaddom; Murad Abualhasan; Rowa Al- Ramah; Naser Shraim; Saed Khammash; Nidal Jaradat (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-01)
    The aim of this study was to formulate a film-coated Valsartan/Amlodipine (VS/AM) immediate release tablets and to evaluate their in vivo release profile. VS/AM core tablets were manufactured using dry granulation method. ...
  • Formulation and evaluation of suspensions: Mefenamic acid prodrugs 
    Kamal Shah; Sushant K; Shrivastava; Pradeep Mishra (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-25)
    Gastrosparing novel prodrugs (MAM and MAT) synthesized consisted of mefenamic acid (MA) with menthol (M) and thymol (T). Structural characterizations of synthesized esters were done by Infra red spectroscopy (IR), proton ...

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