• REVIEW Comparative evaluation of various solubility enhancement strategies for furosemide 

  Ghulam Murtaza; Khan, Shujaat Ali; Muhammad Najam-ul-Haq; Izhar Hussain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-08-01)

  Drugs with good solubility exhibit good oral absorption, and subsequently good bioavailability. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancement of drug solubility. ...
• REPORT Effect of phenological stages on nutritional assessment of ten plant species in Tehsil Takht-e-Nasrati, District Karak, Pakistan 

  Musharaf Khan; Farrukh Hussain; Faridullah; Shahana Musharaf; Abid Salim Haider; Imdadullah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-07-30)

  The proximate analysis of ten plant species from Tehsil takht-e-Nasrati, district Karak was conducted at three phenological stages using standard techniques. The species showed variable results. In the test species, the ...
• REPORT Preliminary phytochemical screening, antimicrobial and antioxidant activities of Euphorbia milli 

  Abdur Rauf; Khan, Ajmal; Nizam Uddin; Muhammad Akram; Mohammad Arfan; Muhammad Qaisar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-07-29)

  Euphorbia milii is a Pakistani herb used for various infectious diseases. In this study we have carried out phytochemical, antibacterial and antioxidant investigation of different extracts/fractions. Phytochemical studies ...
• REPORT Antimicrobial potentials of Mentha longifolia by disc diffusion method 

  Jehan Bakht; Salma Shaheen; Mohammad Shafi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-07-29)

  This study was conducted for the assessment of the antimicrobial activities of different solvents extracted samples from the aerial parts of Mentha longifolia against ten microbial species through the disc diffusion assay ...
• REPORT Evaluation and comparison of different brands of domperidone tablets available in Karachi, Pakistan 

  Khan, Muhammad Qamar; Nighat Razvi; Fakhsheena Anjum; Lubna Ghazal; Saeed Ahmed Siddiqui; Muhammad Harris Shoaib (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-07-28)

  Domperidone is an anti-dopaminergic drug used for the treatment of nausea, vomiting and dyspepsia. It has also been used in Parkinson’s disease. In this study, five different brands of Domeperidone tablets were selected ...
• REPORT Antipyretic activity of hydro-alcoholic extracts of Moringa oleifera in rabbits 

  Saeed Ahmad; Syed Muhammad Ali Shah; Muhammad Khurshid Alam; Khan Usmanghani; Iqbal Azhar; Muhammad Akram (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-27)

  Pyrexia and inflammation are indicatives of various disorders. Modern medicines are available for treatment of pyrexia, but they have few side effects. Several studies are ongoing Worldwide to search natural antipyretic ...
• Determination of pKa values of new phenacyl-piperidine derivatives by potentiometric titration method in aqueous medium at room temperature (25±0.5o C) 

  Shaista Zafar; Shamim Akhtar; Talat Tariq; Noushin Mushtaq; Arfa Akram; Ahsaan Ahmed; Muhammad Arif; Sabahat Naeem; Sana Anwar (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-26)

  Dissociation constant (pKa) of ten novel phenacyl derivatives of piperidine were determined by potentiometric titration method in aqueous medium at room temperature (25 ±0.5o C). The sample solutions were prepared in ...
• Formulation and evaluation of suspensions: Mefenamic acid prodrugs 

  Kamal Shah; Sushant K; Shrivastava; Pradeep Mishra (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-25)

  Gastrosparing novel prodrugs (MAM and MAT) synthesized consisted of mefenamic acid (MA) with menthol (M) and thymol (T). Structural characterizations of synthesized esters were done by Infra red spectroscopy (IR), proton ...
• In vitro/in vivo effect of Citrus limon (L. Burm. f.) juice on blood parameters, coagulation and anticoagulation factors in rabbits 

  Azra Riaz; Rafeeq Alam Khan; Talat Mirza; Tazeen Mustansir; Mansoor Ahmed (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-24)

  The genus Citrus of the family Rutaceae includes many species e.g. Citrus indica, Citrus aurantifolia and Citrus limon, among which Citrus limon L. Burm. f. has been reported to have highest antimicrobial activity. It is ...
• Development and validation of simultaneous estimation method for curcumin and piperine by RP-UFLC 

  Shanmugam Ramaswamy; Gowthamarajan Kuppuswamy; Priyanka Dwarampudi L; Madhuri Kadiyala; Elango Kannan (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-23)

  Curcumin and piperine are proven for their potent medicinal benefits to treat various diseases and they are most commonly used combination in various Indian systems of medicine such as Ayurveda, Siddha and Unani. The ...
• In vitro antimutagenic, antioxidant activities and total phenolics of clove (Syzygium aromaticum L.) seed extracts 

  Bushra Sultana; Farooq Anwar; Muhammad Mushtaq; Maryam Aslam; Sidra Ijaz (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-22)

  The present work explores antimutagenic and antioxidant potential as well as total phenolics of aqueous and acidified methanol extractable components from clove (Syzygium aromaticum L.) seed. The magnitude of ntimutagenic ...
• Synthesis, anticancer activity and structure-activity relationship of some anticancer agents based on Cyclopenta (b) thiophene scaffold 

  Mohamed Said; Hosam Elshihawy (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-21)

  Methods for the synthesis of new heterocyclic systems of thieno (3,2-d)- (1,2,3)-triazine derivatives and N-(3- cyano-5,6-dihydro-4H-cyclopenta (b) thiophene derivatives have been developed. The newly synthesized compounds ...
• Unpredictable chronic mild stress induced behavioral deficits: A comparative study in male and female rats 

  Muhammad Farhan; Huma Ikram; Sumera Kanwa; Darakhshan Jabeen Haleem (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-20)

  Stress is an important precipitant factor for depression. Changes in various body systems that occur in depression are similar to those observed in response to stress. Chronic stress may alter behavioral, neurochemical ...
• Paclitaxel-resistant HeLa cells have up-regulated levels of reactive oxygen species and increased expression of taxol resistance gene 1 

  Wenxiang Bi; Yuxia Wang; Gaoying Sun; Xiaojin Zhang; Yongqing Wei; Lu Li; Xiaoyuan Wang (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-19)

  This study is to establish a paclitaxel (PTX)-resistant human cervical carcinoma HeLa cell line (HeLa/PTX) and to investigate its redox characteristics and the expression of taxol resistance gene 1 (Txr1). HeLa cells were ...
• Hypoglycemic effect of triterpenoid-rich extracts from Euryale ferox shell on normal and streptozotocin-diabetic mice 

  Yuan, Huaibo; Meng, Shaohua; Wang, Guoze; Gong, Zhaobin; Sun, Wenkai; He, Guoqing (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-17)

  The antioxidant effects of the triterpenoid-rich extracts from Euryale ferox shell (ES) have been confirmed in vitro. This study examined whether the triterpenoid-rich extract from ES eases human hyperglycemia and diabetes ...
• Preliminary antioxidant profile of Pistacia integerrima Stewart 

  Abdur Rauf; Ghias Uddin; Haroon Khan; Roohullah (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-16)

  To explore the free radical scavenging properties of crude ethanolic extract of galls, bark, leaves, roots of Pistacia integerrima and its subsequent solvent fractions viz., n-hexane, chloroform, ethyl acetate and ethanol ...
• Simultaneous determination and pharmacokinetics of five rhubarb anthraquinones in dog plasma by HPLC after orally administration the rhubarb extract 

  Feng, Su-xiang; Li, Jian-sheng; Wang, Shu-mei; Yang, Ran; Zhou, Ti-qiang; Li, Xiao-yu; Qu, Ling-bo (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-15)

  Rhubarb is widely used in the treatment of obstipation, gastrointestinal indigestion and other diseases in China and other Asian countries for thousands of years. Anthraquinones are the major group of polyphenol constituents ...
• Senescence related alteration in hippocampal biogenic amines produces neuropsychological deficits in rats 

  Sadia Saleem; Saiqa Tabassum; Sana Ahmed; Tahira Perveen; Saida Haider (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-14)

  Aging is a natural complex process that is regulated at genetic, cellular, molecular and systemic levels and leads to the development of a variety of changes including structural, chemical and genetic in the senescent ...
• Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats 

  Noor Aisyah Ismail; Nor Syafawati Shamsahal Din; Siti Syariah Mamat; Zalina Zabidi; Wan Noraziemah Wan Zainulddin; Farah Hidayah Kamisan; Farhana Yahya; Norhafizah Mohtarrudin; Mohd Nasir Mohd Desa; Zainul Amiruddin Zakaria (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-13)

  The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups ...
• Effect of leaf extracts of Taraxacum officinale on CCl4 induced Hepatotoxicity in rats, in vivo study 

  Muhammad Gulfraz; Dawood Ahamd; Muhammad Sheeraz Ahmad; Rehmatullah Qureshi; Raja Tahir Mahmood; Nyla Jabeen; Kashif Sarfraz Abbasi (Karachi: Faculty of Pharmacy, University of Karachi, 2014-07-12)

  Taraxacum officinale L is a medicinal plant, which has enormous medicinal values against various types of liver disorders and it has traditionally been used for the treatment of liver problems by people from the South ...

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