• Effect of Lactobacillus species on Streptococcus mutans Biofilm formation 

  Ayaz Ahmed; Wu Dachang; Zhou Lei; Liu Jianjun; Qiu Juanjuan; Xin Yi (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-18)

  Streptococcus mutans is the primary pathogen responsible for initiating dental caries and decay. The presence of sucrose, stimulates S. mutans to produce insoluble glucans to form oral biofilm also known as dental plaque ...
• Conformational analysis and geometry optimization of buspirone-A 5-HT1A receptor agonist 

  Huma Ikram; Muhammad Azhar; Muhammad Jamee; Khalida Bano (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-17)

  Buspirone, a partial 5-HT1A receptor agonist, is a clinically prescribed anxiolytic. In the present study, conformational analysis and geometry optimization of buspirone were done as per Hartree-Fock (HF) calculation ...
• Chamomile tea: Herbal hypoglycemic alternative for conventional medicine 

  Saira Saeed Khan; Rahila Najam; Humera Anser; Bushra Riaz; Nausheen Alam (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-16)

  Chamomile is considered as one of the oldest and also documented as medicinal plant. It has shown to be an anti-inflammatory, astringent and antioxidant especially in floral part since ancient times. Recent studies eported ...
• Drug utilization evaluation of meropenem and correlation of side effects with renal status of patients in a teaching based hospital 

  Muhammad Umair Khan; Rabia Ismail Yousuf; Muhammad Harris Shoaib (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-15)

  Meropenem is a restricted, broad spectrum and expensive antibiotic. The major consequences of irrational use of restricted antibiotics are increase drug resistance and drug expenditure. The use of antibiotics, specifically ...
• Haloperidol-induced extra pyramidal symptoms attenuated by imipramine in rats 

  Noreen Samad; Darakhshan Jabeen Haleem (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-14)

  Effects of administration of imipramine (IMI) are determined on haloperidol-induced extrapyramidal symptoms (EPS). Haloperidol is administered orally at a dose of 0.2 mg/rat/day in rats for a period of 5 weeks, by this ...
• Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines 

  Muhammad Ayaz Mustufa; Imran Ali Hashmi; Shahbaz Manzoor; Aamir Ahmed; Viqar-ud-din Ahmed; Afshan Aslam; Cigdem Ozen; Naim ul Hasan Naqvi; Mehmet Ozturk; Firdous Imran Ali (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-13)

  Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological ad biological activities. We have isolated oleanolic acid from methanolic extract of Periploca ...
• Isolation and partial characterization of phosphate solubilizing bacteria isolated from soil and marine samples 

  Talat Yasmeen Mujahid; Khaizran Siddiqui; Rifat Ahmed; Shahana U Kazmi; Nuzhat Ahmed (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-12)

  In the present study the potential of indigenous bacterial isolates from soil rhizosphere and marine environment to promote plant growth was determined. Eight bacterial strains isolated from Soil and marine amples were ...
• Phytochemical screening and Anti-oxidant activity of the two plants Ziziphus oxyphylla Edgew and Cedrela serrata Royle 

  Rizwan Ahmad; Mansoor Ahmad; Mehjabeen; Noor Jahan (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-11)

  Phytochemical studies of medicinal plants are a basic and helping tool for the isolation of active secondary metabolites. The isolation of active compounds is made easy by the help of preliminary phytochemical studies, ...
• Disintegrants combination: Development and optimization of a cefadroxil fast disintegrating tablet 

  Najia Rahim; Syed Baqir Shyum Naqvi; Rehana Bibi; Wajiha Iffat; Sadia Shakeel; Iyad Naeem Muhammad (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-10)

  Fast Disintegrating Tablets (FDTs) is a rapidly growing dosage form preferred for special population (pediatric, geriatric and psychotic patients). It is also developed with the aim of improving bioavailability and ...
• Reversal of haloperidol induced motor deficits in rats exposed to repeated immobilization stress 

  Erum Shireen; Sidra Pervez; Maria Masroor; Wafa Binte Ali; Qudsia Rais; Samira Khalil; Anum Tariq; Darakshan Jabeen Haleem (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-09)

  Stress is defined as a non specific response of body to any physiological and psychological demand. Preclinical studies have shown that an uncontrollable stress condition produces neurochemical and behavioral deficits. The ...
• Drug development of herbomineral capsule (ALG-06) used for hypopigmentation specially in vitiligo 

  Ambreen Huma; Ghazala H. Rizwani; Muhammed Usman; Sumaira Ishaque; Shakeel Ahmed Ansari; Sohail Anwer (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-08)

  Many herbomineral preparations in traditional medicines are being used from time immemorial like Kushta Abrak Safaid, Busoor-e-Labinyah etc. as therapeutics remedies in common ailments such type of preparations are known ...
• Marine green algae Codium iyengarii as a good bio-sorbent for elimination of reactive black 5 from aqueous solution 

  Rafia Azmat (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-07)

  The green seaweeds Codium iyengarii (C. iyengarii) was used to prepare as an adsorbent surface for the deletion of Reactive Black 5 (RB 5) from aqueous solution via adsorption. The batch technique was adopted under the ...
• Enhanced production of maltase (α-glucosidase) from newly isolated strain of Bacillus licheniformis KIBGE-IB4 

  Muhmmad Asif Nawaz; Zainab Bibi; Afsheen Aman; Raheela Rahmat Zohra; Shah Ali Ul Qader (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-06)

  Maltase (alpha-glucosidase) hydrolyzes α-(1→4) glucosidic bond of maltose into two glucose molecules. It is widely used in various foods, beverages and also in textile and biofuel industries. During current study, ...
• St. John’s Wort increases brain seotonin synthesis by inhibiting hepatic tryptophan 2, 3 dioxygenase activity and its gene expression in stressed rats 

  Samina Bano; Iffat Ara; Kausar Saboohi; Tariq Moattar; Chaoudhry, Bushra (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-05)

  We aimed to investigate the effects of herbal St. John’s Wort (SJW) on transcriptional regulation of hepatic tryptophan 2, 3 - dioxygenase (TDO) enzyme activity and brain regional serotonin (5-HT) levels in rats exposed ...
• Antidepressant effect and categorization of Inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn 

  Raheela Khursheed; Ghazala H Rizwani; Viqar Sultana; Maryam Ahmed; Arfa Kamil (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-04)

  Trigonella foenum- graecum Linn (Fabaceae) is an annual aromatic herb and no wit is cultivated globally like in Pakistan, Egypt, India, Middle East etc. Traditionally it was used in anorexia, as febrifuge, to soothe ...
• Adverse effects on cardiovascular status and lipid levels of albino Wistar rats treated with cisplatin and oxaliplatin in combination with 5 Fluorouracil 

  Rahila Najam; Nusrat Bano; Talat Mirza; Saba Hassan (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-03)

  The study was designed to comparatively assess direct damages on cardiac tissues and aorta associated with abnormalities in lipid profile and cardiac biomarkers induced by two platinum cytotoxic compounds with and without ...
• Synthesis of novel derivatives of 4-Pyridine carboxylic acid hydrazide and their activity on central nervous system 

  Sabahat Naeem; Shamim Akhtar; Nousheen Mushtaq; Arfa Kamil; Shaista Zafar; Sana Anwar; Muhammad Arif (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-02)

  : Six novel derivatives (2-7) of 4-Pyridine carboxylic acid hydrazide (PCH) were synthesized by treating this lead molecule with substituted arylsulphonyl and benzoyl chlorides. The molecular structures of the newly derived ...
• Formulation and stability evaluation of immediate release antioxidant tablet 

  Abida Sultana; Fouzia Hassan; Fozia Israr; Syed Muhammad Farid Hasan; Naheed Haque (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-01)

  Oxidative stress plays an important part in the development of human diseases. Pharmaceutical strategies are required to be work out in order to fight against such oxidative damages. Designing of new formulations that can ...
• Natural antiemetics: An overview 

  Salman Ahmed; Muhammad Mohtasheemul Hasan; Syed Waseemuddin Ahmed (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-27)

  : Emesis encompasses the forceful expulsion of the contents of stomach via the mouth or sometimes the nose. The adverse effects of currently available anti-emetic agents potentiate the natural product researchers to explore ...
• Comprehensive review on therapeutic strategies of gouty arthritis 

  Muhammad Akram; Khan, Usmanghani; Iqbal Ahmed; Iqbal Azhar; Abdul Hamid (Karachi: Faculty of Pharmacy, University of Karachi, 2014-09-26)

  Traditional medicines are practiced worldwide for treatment of gouty arthritis since ancient times. Herbs and plants always have been used in the treatment of different diseases such as gout. The present article deals ...

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