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Browsing Issue No.2 (Supplementary) by Issue Date

Browsing Issue No.2 (Supplementary) by Issue Date

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  • Cloning, expression and characterization of the maltooligosyl trehalose synthase from the archaeon Sulfolobus tokodaii 
    Zhao, Meng; Xu, Xiangqun; Yang, Shaolong; Liu, Tianming; Liu, Bo (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-01)
    The maltooligosyl trehalose synthase gene from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7 was cloned and the recombinant peotein was expressed in E. coli. The protein was purified to homogeneity by nickel ...
  • Effect of caffeine on anti-clotting activity of warfarin in healthy male albino rabbits 
    Shamaila Zafar; Muhammad Mudassar Ashraf; Asghar Ali; Nosheen Aslam; Asma Ashraf; Sara Zafar; Rahat Andleeb; Muhammad Waqas Khadam; Imtiaz Mahmood Tahir; Muhammad Akram; Shah, Syed Muhammad Ali; Muhammad Daniyal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-03)
    Drug-drug interactions are most commonly occurring phenomenon in clinical practice. Many physicians are afraid of being involved in an allegation of malpractices due to the occurrence of any severe interaction. ...
  • Prevalence of statin induced myopathy in Lahore, Pakistan 
    Saleha Sadeeqa; Mariam Maqsood; Maqsood Ahmad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-04)
    Cardiovascular diseases are considered to be the leading cause of disability and deaths in the whole world. The major cause behind this disease is the formation of lipid plagues in the form of thrombus. The statins (HMG-CoA ...
  • Development and validation of a stability-indicating RP-HPLC-FLD method for determination of 5-[(4-chlorophenoxy) methyl]-1, 3, 4- oxadiazole-2-thiol; A novel drug candidate 
    Naureen Shehzadi; Khalid Hussain; Muhammad Islam; Nadeem Irfan Bukhari; Noman Asif; Khan, Muhammad Tanveer; Muhammad Salman; Shaista Qamar; Sajida Parveen; Fakhra Zahid; Arshad Ali Shah; Abida Bilal; Abbasi, Muhammad Athar; Sabahat Zahra Siddiqui; Aziz-Ur-Rehman (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-04)
    The present study describes the development and validation of a simple high performance liquid chromatographic method for the determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1, 3, 4- oxadiazole-2-thiol. ...
  • Comparative antioxidant and antidiabetic effects of Syzygium polyanthum leaf and Momordica charantia fruit extracts 
    Muhammad Jihad Sandikapura; Shaik Nyamathulla; Mohamed Ibrahim Noordin (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-05)
    The study was aimed to perform aqueous extraction of two plants using different extraction methods, and evaluate their antioxidant and antidiabetic potential. Plant materials were extracted by maceration, soxhlet, sonication ...
  • Antihyperglycemic effect of Conocarpus erectus leaf extract in alloxaninduced diabetic mice 
    Syed Ali Raza; Chaudhary, Ayoub Rashid; Muhammad Waseem Mumtaz; Abdul Ghaffar; Ahmad Adnan; Abdul Waheed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-06)
    Synthetic drugs have widely been helpful in management of diabetes mellitus type 2. However, side effects associated with synthetic drugs serve as an impetus to explore plants as alternate mode of treatment. The hydroethanolic ...
  • Effects of superdisintegrants in oral dissolving formulation of cinitapride tablets 
    Atta-Ur-Rehman; Rabia Bushra; Anwar Ejaz Beg; Huma Ali; Farya Zafar; Maria Ashfaq; Shazia Alam; Omer Mustapha; Shumaila Shafique (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-07)
    The initiation of newer techniques and development of mouth dissolving (MD) products has created new avenues of higher patients’ compliance. MD formulations are actually lessen the difficulties associated with solid ...
  • Prevention and treatment of osteoporosis caused by oestrogen shortage in rats 
    Zhang, Wei; Zheng, Lili (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-08)
    Through castrated rats osteoporosis models, this study aims to explore whether the intraperitoneal injection of Scutellaria baicalensis extract could prevent the occurrence of osteoporosis and slow down/reverse osteoporosis ...
  • Evaluation of antibiotic resistant bacteria in underground drinking water and transfer of their resistant character to normal flora of the body 
    Mehboob Alam; Khan, Naqab; Khurram Rehman; Khan, Samiullah; Zahid Rasul Niazi; Kifayatullah Shah; Natasha Baloch; Khan, Barkat Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-09)
    The untreated surface water for drinking and domestic use is an alarming situation to public health especially in prevalence of antibiotics resistant bacteria. This investigation aimed to isolate and identify the antibiotic ...
  • Ameliorative effect of hydro-methanolic extract from roots of Rauwolfia serpentina on some biochemical parameters of type 1 diabetic mice 
    Muhammad Bilal Azmi; Shamim A. Qureshi; Syed Danish Haseen Ahmed; Hina Akram Mudassir; Fauzia Imtiaz; Sumera Rais; Khan, Auwais Ahmed; Muhammad Ahsan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-10)
    Present work seeks to investigate the biochemical parameters in terms of hypoglycemic and hypolipidemic effects of hydro-methanolic roots extract (HyMREt) of Rauwolfia serpentina in type 1 (alloxan induced) diabetic mice. ...
  • Incidence of drug interactions in intensive care units in tertiary care settings: Classification, facts and measures 
    Hina Hasnain; Huma Ali; Farya Zafar; Ali Akbar Sial; Shazia Alam; Anwar Ejaz Beg; Rabia Bushra; Mehwish Rizvi; Khan, Maqsood Ahmed; Huma Shareef; Ghazala R Naqvi; Anum Tariq (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-11)
    Drug-drug interactions (DDIs) are extremely significant concern, particularly in sensitive population including pediatric and geriatric. Propensity for the development of DDIs is high in patients admitted at intensive ...
  • Antioxidant capacity and polyphenolic content of the Echinocystis lobata (Michx.) Torr. et A.Gray flowers 
    Ielciu, Irina; Hanganu, Daniela; Păltinean, Ramona; Vlase, Laurian; Frédérich, Michel; Gheldiu, Ana-Maria; Benedec, Daniela; Crişan, Gianina (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-12)
    Echinocystis lobata (Michx.) Torr. et A.Gray is a spontaneous species in the Romanian flora, lesser studied by scientific literature, but which has proved significant activities in traditional medicine. The present study ...
  • Lethal toxic Dose (i.p LD50), total protein contents and comparative hemolytic potential of (99mTc labeled & non-labeled) Naja naja karachiensis venom 
    Bin Asad, Muhammad Hassham Hassan; Arooj Fatima Asad; Sumbal Bibi; Kaleem Ullah; Tariq Javed; Majeed Ullah; Atif Ali; Zia-ur-Rahman Qureshi; Muhammad Imran Amirzada; Yasser MSA Al-Kahraman; Syed Muhammad Farid Hasan; Jean-Marc Sabatier; Albert Rizvanov (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-13)
    Recent recognition about snake bite envenomation on June, 2017 as neglected tropical disease under categoryA by World Health Organization advocated again its undeniable importance. Present circumstances reasoned to work ...
  • Drug utilization and prescribing pattern of antibiotics in a tertiary care setups; trends and practices 
    Huma Ali; Farya Zafar; Shazia Alam; Anwar Ejaz Beg; Rabia Bushra; Ammara Manzoor; Ghazala R Naqvi; Riffat Yasmeen; Yousra Shafiq; Anum Tariq; Saba Zubair; Saima Saleem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-14)
    Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization ...
  • Prophylactic mechanisms of Cucumis melo var. flexuosus and Phoenix dactylifera fruit extracts against diabetic cardiomyopathy in streptozotocin induced diabetic rats 
    Amna Ali Saddi; Azza Mostafa Mohamed; Shaikh, Abdulkader Mohamed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-15)
    The aim of this investigation was to study the antidiabetic impact of Cucumis melo var. flexuosus and/or Phoenix dactylifera fruit aqueous extracts and their mechanisms in repressing diabetes induced cardio-myopathy in ...
  • Structural and functional annotation of citrate synthase from Aspergillus niger ANJ-120 
    Ghulam Mustafa; Rawaba Arif; Shazia Anwer Bukhari; Muhammad Ali; Sumaira Sharif; Asia Atta (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-16)
    Citrate synthase (CS) is involved in citric acid biosynthesis which is a well-established metabolic pathway. The condensation of acetyl-CoA with oxaloacetate is catalyzed by CS. Citric acid (CA) has a number of applications ...
  • Homeostasis model assessment of insulin resistance in non-diabetic heart failure patients: A case-control investigation at tertiary care Hospitals of Karachi 
    Muhammad Ahsan; Muhammad Bilal Azmi; Syed Danish Haseen Ahmed; Sheikh, Sadia Ikhlaque; Hina Akram Mudassir; Tehseen Iqbal; Fauzia Imtiaz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of KarachiHomeostasis model assessment of insulin resistance in non-diabetic heart failure patients: A case-control investigation at tertiary care Hospitals of Karachi, 2018-03-17)
    Heart failure is a progressive, chronic disorder. Insulin resistance (IR) has been more and more involved as a preliminary metabolic perturbance predisposing to hyperglycemia, hyperlipidemia and atherosclerosis with others ...
  • Interaction of palladium inorganic salt and organic complex with glutathione content of liver homogenate 
    Muhammad Mukhtiar; Syed Umer Jan; IhsanUllah; Rahman Gul; Abid Hussain; Essa Ali; IzharUllah; Abdul Jabbar; Muhammad Akram; Sibghat Mansoor; Khan, Muhammad Farid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-03-18)
    Glutathione is an essential antioxidant of living organism that provides a primary protection against metals toxicity. A significant amount of glutathione is present in blood erythrocytes, plasma and liver hepatocytes to ...

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