Issue 03: Recent submissions

  • Renin Angiotensin Aldosterone System (RAAS): Its biology and drug targets for treating diabetic nephropathy 
    Maryam Zain; Awan, Fazli Rabbi (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    Diabetes mellitus is a multifactorial disorder of hyperglycemia caused by a combination of biochemical, molecular and genetic factors, which leads to the dysfunction of various organs including kidneys. Diabetic nephropathy ...
  • Prostate cancer: Leading and misleading routes to TRAIL of death 
    Farooq, Ammad Ahmad; Qureshi, Muhammad Zahid; Abdur Rehman; Nogueira, Daniele Rubert; Awan, Imrana Iftikhar; Adeela Shahid (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)
    Prostate cancer is a multifaceted disease that arises because of misrepresentation of linear and integrated signaling cascades that regulate gene network in normal and cancer cells. Programmed cell death is modulated by ...
  • MINI REVIEW Chronic obstructive pulmonary disease, its new drug treatments and strategies: A review 
    Muhammad Hanif; Junaid Qureshi; Hira Ijaz; Muhammad Iqbal Mustafa; Akhtar Rasul; Naeem Amir; Basma Aftab; Ahad Fayyaz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-06-02)
    COPD is a complicated disease. Current available treatments are just for symptomatic relief and they cannot reverse the damages to lungs tissues due to alveolar destruction in COPD. Research is being conducted to evaluate ...
  • REPORT An ex vivo up-take of levamisole molecules by cestode (Monezia expensa) of goat (Capra hirsa) and its detection through RP-HPLC 
    Muhammad Mazhar Ayaz; Muhammad Sajid; Das, Sanjota Nirmal; Muhammad Hanif (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-06-01)
    Detection of various molecules of drugs remained a prime issue especially in tissues of animals, humans and in their target parasites. The cestode/tapeworms pose a dilemma because of their weird body composition and uptake ...
  • REPORT Comparison of qualitative, quantitative analysis and antioxidant potential between wild and cultivated Borago officinalis leaves from palestine 
    Hassan Abu-Qaoud; Nuha Shawarb; Fatima Hussen; Nidal Jaradat; Munqez Shtaya (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-31)
    Borago officinalis plant is an important plant of high medicinal and nutritional values. This study designed to evaluate antioxidant activity, screen the existence of phytogenic chemical compounds and to determine the ...
  • REPORT Phytochemical screening and antimicrobial activities of red silk cotton tree (Bombax ceiba L.) 
    Syed Sadaqat Shah; Syed Salim Shah; Arshad Iqbal; Sajjad Ahmed; Khan, Wisal Muhammad; Saddam Hussain; Li, Zhijian (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-30)
    The present study was conducted to investigate the phytochemical screening and antimicrobial activities of stem bark of Bombax ceiba L. The methanol extract was subjected to qualitative phytochemical screening using ...
  • REPORT Insight into the lipophilicity of selected monosubstituted chalcones 
    Sandeep Sankaran; Balasubramanian, Ranganathan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-29)
    This study represents our attempt to understand how the antimicrobial activity of chalcones is modulated by their lipophilicity. To achieve this overall objective, a library of monosubstituted chalcones was targeted after ...
  • Screening and characterization of selected drugs having antibacterial potential 
    Hina Javed; Sobia Tabassum; Shazia Erum; Iram Murtaza; Aish Muhammad; Farhana Amin; Muhammad Farrukh Nisar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-27)
    Due to ever increasing antibiotic resistance offered by pathogenic bacterial strains and side effects of synthetic antibiotics, thereof, there is a need to explore the effective phytochemicals from natural resources. In ...
  • Potential impact of Panax ginseng against ethanol induced hyperlipidemia and cardiac damage in rats 
    Najla Othman Ayaz; Hanan Saeed Alnahdi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-27)
    The objective of the current work was to explore the possible hypolipidemic and therapeutic impacts of Panax ginseng against cardiac damage in response to ethanol ingestion in male and female rats. 10% ethanol was ingested ...
  • Antagonistic behaviour of organic compounds from Bacillus species and Brevundimonas specie 
    Hina Sadiq; Nazia Jamil (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-26)
    Bacterial strains, Bacillus cereus Lb (KF011486), Brevundimonas sp. A2 (JX996070), Bacillus cereus AZS and Bacillus sp. 11A, isolated from soil sample, were checked for their antimicrobial property against Bacillus as ...
  • Extraction of biomedical compounds from the wood of Pterocarpus macarocarpus Kurz heartwood 
    Jiang, Tao; Li, Kaifu; Liu, Honghai; Yang, Lin (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-25)
    Some wood can be used as traditional Chinese medicine. The medicinal value of wood is associated with its extractives. Pterocarpus macarocarpus Kurz heartwood is a kind of top valuable reddish hardwood in making furniture ...
  • Measuring central percentiles of blood pressure levels among adults in Pakistan: A case study of Rawalpindi 
    Sumaira Mubarik; Muhammad Aslam (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-24)
    The prevalence pattern of hypertension (HTN) in developing countries is different from that in the developed countries. In Pakistan, the percentage of hypertensive patients has been growing since last two decades. Various ...
  • Therapeutic effect evaluation of reteplase on acute pulmonary embolism 
    Wang, Wanping; Zhao, Xianping; Ren, Yingjie; Qiao, Ping (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-23)
    Thrombolysis is the main therapeutic method of acute pulmonary embolism (APE). In order to investigate the efficacy of reteplase on APE and the changes of cytokines in the progression of APE, 72 patients with APE were ...
  • Role of Leptin and dyslipidemia in chronic kidney disease 
    Sabeela Noor; Faiza Alam; Syeda Sadia Fatima; Mahnur Khan; Rehana Rehman (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-22)
    Chronic kidney disease (CKD) patients are at an increased risk of cardiovascular complications and plasma leptin level is elevated in cardio renal syndrome. We wanted to explore leptin levels in patients with different ...
  • Delivery of risperidone from gels across porcine skin in vitro and in vivo in rabbits 
    Ning, Yuming; Chen, Xiaojin; Yu, Zhenwei; Liang, Wenquan; Li, Fanzhu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-21)
    The purpose of this study was to develop and evaluate a transdermal delivery system for RIS using hydrogels. First, the effects of different concentrations of hydroxypropyl methylcellulose and Carbomer 934 (CBR) on ...
  • Phycochemical and pharmacological studies on Ulva fasciata Delile 
    Maryam Anis; Afshan Yasmeen; Sadia Ghousia Baig; Salman Ahmed; Munawwar Rasheed; Muhammad Mohtasheemul Hasan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-20)
    Phycochemical and pharmacological studies were carried out on Ulva fasciata Delile. The ash content was found as 20.4812 % dry weight, moisture content 14.5514 %, total fat content as 0.1878% and 0.49341 %. Total carbohydrate ...
  • Quantitative determination of mogroside V in rat plasma by LCMS/MS and its application to a pharmacokinetic study 
    Yan, Huiyu; Tao, Lina; Qu, Xiaoyu; Zhou, Liting; Zhang, Sixi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-19)
    Mogroside V is the most abundant (approximately 0.50%) cucurbitane-type triterpene glycoside in Siraitia grosvenorii and exhibits significant antitussive, expectorant, anti-carcinogenic, and anti-inflammatory effects. A ...
  • Synthesis of some new 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides as potent antibacterial agents 
    Ghulam Hussain; Abbasi, Muhammad Athar; Aziz-ur-Rehman; Sabahat Zahra Siddiqui; Syed Adnan Ali Shah; Irshad Ahmad; Muhammad Shahid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-18)
    In this work, a new series of 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides has been synthesized and evaluated for their antibacterial potential. The synthesis was initiated by the reaction of different ...
  • The increasing of catalase activity in dimethylbenz-α-anthracene (DMBA) induced rat treated by Hibiscus sabdariffa L extract 
    Nurkhasanah; Nanik Sulistyani; Fatmawati, Ery (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-16)
    The objective of the present study was to characterize the activity and expression of catalase enzymes in Hibiscus sabdariffa L (rosella) extract treated rat induced by dimethylbenz-α-anthracene (DMBA) and to evaluate the ...
  • Phytochemical analysis, phytotoxic and insecticidal activities of medicinally important Periploca hydaspidis 
    Rafi Ullah; Jehan Bakht; Mohammad Shaf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-16)
    The present study investigates the phyto-chemical analysis, phytotoxic activity and insecticidal activity of the stem and root tissues of medicinally important Periploca hydaspidis. All the extracted samples exhibited the ...

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