• Enhanced production of streptokinase from Streptococcus agalactiae EBL-31 by response surface methodology 

  Arooj Arshad; Muhammad Anjum Zia; Muhammad Asgher; Joyia, Faiz Ahmad; Muhammad Arif (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-23)

  Streptokinase (SK) is a fibrinolytic protein used for the treatment of cardiovascular disorders. In the present study, enhanced production of SK was achieved by determining the optimum fermentation conditions for the ...
• Molecular basis of quinolone resistance in clinical isolates of Klebsiella pneumoniae from Pakistan 

  Roman Farooq Alvi; Bilal Aslam; Naveed Shahzad; Muhammad Hidayat Rasool; Muhammad Shafique (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-21)

  Antibiotic resistant Klebsiella pneumoniae, is associated with various nosocomial infections that are difficult to treat. This study is designed to find out the patterns of resistance against commonly used antibiotics in ...
• Enhanced production of Lovastatin by filamentous fungi through solid state fermentation 

  Naveed Munir; Muhammad Asghar; Mian Anjum Murtaza; Naheed Akhter; Ghulam Rasool; Syed Muhammad Ali Shah; Imtiaz Mahmood Tahir; Khan, Fahad Said; Muhammad Riaz; Sabira Sultana; Sabira Sultana; Muhammad Akhlaq; Muhammad Akram (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-20)

  Lovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with ...
• Role of ibuprofen and lavender oil to alter the stress induced psychological disorders: A comparative study 

  Sara Qadeer; Shaista Emad; Shaista Emad; Sarwat Yousuf; Sheeza Sheikh; Yousra Sarfaraz; Sana Sadaf; Saida Haider (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-19)

  Stress has become an integral feature of everyday living. Each individual that lives encounters some manifestation of stress in life. Stress causes certain alterations in the structure and functions of the body and is ...
• High performance liquid chromatographic method validation for determination of rosuvastatin calcium in tablet dosage forms 

  Madiha Moid; Sidra Afzal; Najia Rahim; Tariq Ali; Wajiha Iffat; Lubna Bashir; Shazia Naz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-18)

  A precise, sensitive and quick High Performance Liquid Chromatographic (HPLC) method for the determination of rosuvastatin calcium in bulk and tablet dosage forms has been validated. The chromatographic scheme involved: ...
• Single or multiple encounters of general anaesthesia do not cause any cognitive dysfunction: Findings from a retrospective population-based, case-control study 

  Huang, Zeqing; Wang, Nan; Suo, Liangyuan; Wang, Mingyu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-17)

  General anesthesia and surgery have been associated with acute cognitive impairment in several elderly individuals. Present study was conducted to determine whether the general anaesthesia exposure and cognitive dysfunction ...
• Post interferon therapy decreases male fertility through gonadotoxic effect 

  Shazia Anwer Bukhari; Muhammad Masood Ahmed; Fozia Anjum; Haseeb Anwar; Syed Ali Raza Naqvi; Tauseef Zahra; Uzma Batool (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-17)

  Prevalence of hepatitis C virus (HCV) has been seen in more than 15% of Pakistani population. For the treatment of this infection, only two medicines, interferon, and ribavirin were approved in 1998. The concerned physicians ...
• Comparative evaluation of antibacterial activity of foot muscle extracts from genus Physa and genus Ceciloides (Mollusca: Gastropoda) 

  Javaria Altaf; Muhammad Hidayat Rasool; Saira Akhtar; Maleeha Manzoor; Tahira Younas; Bakhtawer Ansari; Gulraiz Ahmad; Farhat Jabeen; Muhammad Ali; Rizwan Munir (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-15)

  The aim of this study is to explore the presence of antimicrobial bioactive agents in the foot muscle extracts of snails belonging to genus Physa and Ceciloides. Antibacterial activity of foot extracts belonging to species ...
• Synthesis, characterization and evaluation of antibacterial activity of copper oxide nanoparticles against clinical strains of Staphylococcus aureus 

  Naheed Niaz; Asma Bano; Fehmida Fasim; Rehana Kausar; Khan, Barkat Ali; Naheed Zafar; Khan, Samiullah; Bushra Uzair (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-14)

  Bacterial resistance is spreading globally due to excessive use of antibiotics, making it one of our times biggest challenges. To address this issue present study was conducted to evaluate the antibacterial activity of ...
• Anti-diabetic activity of aqueous extract of Ipomoea batatas L. in alloxan induced diabetic Wistar rats and its effects on biochemical parameters in diabetic rats 

  Shagufta Kamal; Naheed Akhter; Khan, Samreen Gul; Shumaila Kiran; Tahir Farooq; Muhammad Akram; Syed Muhammad Ali Shah; Imtiaz Mahmood Tahir; Muhammad Akhlaq; Fahad Said; Jawad Zaheer (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-13)

  Diabetes is a condition where the fasting blood glucose level elevated above the normal range (80-120mg/dL). This increase in blood glucose level may be due to the insulin deficiency i.e. insulin dependent diabetes mellitus ...
• Piperine attenuates the cancerous activity response in Neuro-2a cell line 

  Sonia Siddiqui; Aiman Kanwal; Khawar Saeed Jamali; Priya Tufail; Aisha Kamal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-12)

  Interactions of cancer cells with their microenvironment play a significant role in defining the severity of the disease. In search of novel compounds with anti-inflammatory and anticancerous capabilities, the effects of ...
• Phytochemical screening, antioxidant and in vivo neuropharmacological effect of Monotheca buxifolia (Falc.) barks extract 

  Samiullah Burki; Mehjabeen; Zeba Gul Burki; Zafar Ali Shah; Muhammad Imran; Muhammad Khan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-11)

  Owing to its pharmacological versatility, the current study focuses the evaluation of Monotheca buxifolia (M. buxifolia) bark crude extract and its fractions for phytochemical and pharmacological analysis. Phytochemical ...
• Potent antioxidative DNA damage of selected Saudi medicinal plants in cultured human lymphocytes 

  Haytham Mahmoud Daradka; Omar Flah Khabour; Mohammad Kdaimes Alotaibi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-10)

  Oxidative stress is a condition that might predispose the individuals to diseases including cancer. The 8- hydroxydeoxyguanosine (8-OHdG) is a marker that reflects oxidative DNA damage in the body. In this study, seven ...
• Conventional versus microwave assisted synthesis, molecular docking and enzyme inhibitory activities of new 3,4,5-trisubstituted-1,2,4- triazole analogues 

  Naeem Akhtar Virk; Aziz-ur-Rehman; Abbasi, Muhammad Athar; Sabahat Zahra Siddiqui; Umer Rashid; Javed Iqbal; Muhammad Saleem; Muhammad Ashraf; Wardah Shahid; Syed Adnan Ali Shah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-08)

  N-(Substituted)-5-(1-(4-methoxyphenylsulfonyl)piperidin-4-yl)-4H-1,2,4-triazol-3-ylthio) acetamide were synthesized by following conventional as well as microwave assisted protocol through five consecutive steps under the ...
• Evaluation of 99mTc-sulfadiazine as Bacillus microorganisms infection imaging agent using animal model 

  Muhammad Tauqeer Ahmed; Muhammad Yameen; Bushra Munir; Sadia Asim; Muhammad Usman; Syed Ali Raza Naqvi; Jawad Akhtar Hussain Gillani; Rashid Rasheed; Muhammad Adeel Shahzad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-08)

  Bacterial infection is one of the vital sources of morbidity and mortality. The development of single photon emission computed tomography (SPECT) radiotracer agents using antibiotics, for targeting in-vivo bacteria, helps ...
• Development and validation of HPLC method for the determination of pioglitazone in human plasma 

  Syed Imran Ali; Nighat Razvi; Syed Mohammad Farid Hasan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-07)

  Pioglitazone is widely used for the management of type–II diabetes mellitus. The objective of the present study was to develop a simple and cost-effective HPLC method for the quantification of pioglitazone in human plasma. ...
• Efficacy of Azadirachta indica organic extracts against clinical methicillin resistant Staphylococcus aureus isolates 

  Jaweria Anwar; Muhammad Asif Zahoor; Muhammad Kashif Zahoor; Abu Baker Siddique; Zeeshan Nawaz; Muhammad Hidayat Rasool; Muhammad Usman Qamar; Muhammad Waseem; Syed Zajif Hussain; Aysha Yasmin (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-06)

  In current study we investigated the efficacy of organic extracts of Azadirachta indica leaves against Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates. For this purpose fresh leaves were used to prepare ...
• Ameliorating role of methanolic leaves extract of Fraxinus xanthoxyloides against CCl4-challanged nephrotoxicity in rats 

  Tahira Younis; Azhar Rasul; Faiza Jabeen; Ghulam Hussain; Javaria Altaf; Laila Jafri; Rehana Rani; Khan, Muhammad Rashid; Iqra Sarfraz; Muhammad Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-05)

  Roots, bark, stem/twigs, and leaves of Fraxinus xanthoxyloides are being used regionally for the cure of malaria, jaundice, internal injuries, pneumonia, pain, rheumatism and also in fracture of bones. Our objective was ...
• Biowaiver studies of newly optimized meloxicam tablets 

  Farya Zafar; Khan, Sohail; Huma Ali; Shabana N. Shah; Rabia Bushra; Ghazala Raza Naqvi; Kashif Maroof; Khan, Maqsood Ahmed; Zeb un Nisa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-04)

  In this research work biowaiver studies of newly developed and optimized Meloxicam 7.5mg and 15mg water dispersible formulations were carried out at different dissolution media i.e. 0.1N HCl, phosphate buffer pH 4.5, pH ...
• Spectrophotometric investigation of Glutathione modulation by Thallium chloride in aqueous medium 

  Khan, Muhammad Jalil; Muhammad Mukhtiar; Qureshi, Muhammad Murtaza; Syed Umer Jan; IzharUllah; Abid Hussain; Khan, Muhammad Farid; Rahman Gul; Nisar Ahmad Shahwani4; Imran Rabbani (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-03)

  Thallium has been shown to significantly influence various tissues of living organisms; Exposure to Thallium can disturb mitochondrial function, degenerate neurons, and interfere with the function of critical metabolic ...

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